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2. Stem cell transplantation for articular cartilage repair

   en.wikipedia.org/wiki/Stem_cell_transplantation...

   As a result, many researchers have focused on adult stem cells, [3] or stem cells isolated from adult humans that can be transplanted into damaged tissue. Because of their multi-potent capabilities, mesenchymal stem cell (MSC) lineages have been used successfully in animal models to regenerate articular cartilage and in human models to ...

3. Stem-cell therapy - Wikipedia

   en.wikipedia.org/wiki/Stem-cell_therapy

   Stem-cell therapy uses stem cells to treat or prevent a disease or condition. [1] As of 2024, the only FDA-approved therapy using stem cells is hematopoietic stem cell transplantation. [2] [3] This usually takes the form of a bone marrow or peripheral blood stem cell transplantation, but the cells can also be derived from umbilical cord blood.

4. Adult stem cell - Wikipedia

   en.wikipedia.org/wiki/Adult_stem_cell

   A stem cell possesses two properties: . Self-renewal is the ability to go through numerous cycles of cell division while still maintaining its undifferentiated state. Stem cells can replicate several times and can result in the formation of two stem cells, one stem cell more differentiated than the other, or two differentiated cells.

5. Bone marrow failure - Wikipedia

   en.wikipedia.org/wiki/Bone_marrow_failure

   For those with severe bone marrow failure, the cumulative incidence of resulting stem cell transplantation or death was greater than 70% by individuals 60 years of age. [13] The incidence of bone marrow failure is triphasic: one peak at two to five years during childhood (due to inherited causes), and two peaks in adulthood, between 20 and 25 ...

6. Osteoarthritis - Wikipedia

   en.wikipedia.org/wiki/Osteoarthritis

   Osteoarthritis is the most common form of arthritis, affecting about 237 million people or 3.3% of the world's population as of 2015. [4] [12] It becomes more common as people age. [1] Among those over 60 years old, about 10% of males and 18% of females are affected. [2] Osteoarthritis is the cause of about 2% of years lived with disability. [12]

7. Graft-versus-host disease - Wikipedia

   en.wikipedia.org/wiki/Graft-versus-host_disease

   Prochymal is the first stem cell drug to be approved for a systemic disease. [50] In January 2016, Mesoblast released results of a phase 2 clinical trial on 241 children with acute Graft-versus-host disease, that was not responsive to steroids. [51] The trial was of a mesenchymal stem cell therapy known as remestemcel-L or MSC-100-IV. Survival ...