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Depression may be related to the same brain mechanisms that control the cycles of sleep and wakefulness. Depression may be related to abnormalities in the circadian rhythm, [24] or biological clock. A well synchronized circadian rhythm is critical for maintaining optimal health.
Anxiety is an emotion characterised by an unpleasant state of inner turmoil and includes feelings of dread over anticipated events. [1] [2] [3] Anxiety is different from fear in that fear is defined as the emotional response to a present threat, whereas anxiety is the anticipation of a future one. [4]
Watson and Clark (1991) proposed the Tripartite Model of Anxiety and Depression to help explain the comorbidity between anxious and depressive symptoms and disorders. [1] This model divides the symptoms of anxiety and depression into three groups: negative affect, positive affect and physiological hyperarousal.
Depression can have multiple, sometimes overlapping, origins. Depression can be a symptom of some mood disorders, some of which are also commonly called depression, such as major depressive disorder, bipolar disorder and dysthymia. [7] Additionally, depression can be a normal temporary reaction to life events, such as the loss of a loved one.
Depressive anxiety is a term developed in relation to the depressive position by Melanie Klein, building on Freud's seminal article on object relations of 1917, 'Mourning and Melancholia'. [1] Depressive anxiety revolved around a felt state of inner danger produced by the fear of having harmed good internal objects [ 2 ] - as opposed to the ...
The brain parenchyma refers to the functional tissue in the brain that is made up of the two types of brain cell, neurons and glial cells. [7] It is also known to contain collagen proteins. [8] Damage or trauma to the brain parenchyma often results in a loss of cognitive ability or even death.
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