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MALT (mucus-associated-lymphoid tissue) lymphoma is a rare subtype of non-Hodgkin lymphoma. It affects the tissue that lines your organs and other areas of your body. It grows very slowly and often doesn’t cause noticeable symptoms.
Extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue, or MALT lymphoma, is a slow-growing type of non-Hodgkin lymphoma that develops in the lymphoid tissue outside the lymph nodes. MALT lymphoma is the most common form of marginal zone lymphoma , though it’s still rare.
MALT lymphoma (also called MALToma) is a form of lymphoma involving the mucosa-associated lymphoid tissue (MALT), frequently of the stomach, but virtually any mucosal site can be affected. It is a cancer originating from B cells in the marginal zone of the MALT.
MALT lymphoma is a slow growing lymphoma, usually diagnosed in the stomach (gastric MALT). But they can also develop in the lung, thyroid, salivary glands, eye, skin or soft tissues (non gastric MALT).
Mucosa-associated lymphoid tissue (MALT) lymphoma is an uncommon form of non-Hodgkin lymphoma (NHL). Unlike most lymphomas that begin growing within lymph nodes, this type of lymphoma typically arises from tissue that is present in the lining of certain other organs of the body.
MALT lymphoma is related to Helicobacter pylori infection. Regression of gastric MALT lymphoma can be done in the early stages of the disease by eradication therapy. The majority of cases with MALT lymphoma are cured by eradication therapy, but there are cases that need to be treated with rituximab alone or in combination with other drugs.
Mucosa-associated lymphoid tissue (MALT) lymphoma is categorised as indolent or low-grade B-cell lymphoma; however, high-grade histological transformation can occur. Median age at presentation is approximately 60 years.
MALT lymphoma - Knowledge @ AMBOSS
Like all types of lymphoma, MALT lymphoma occurs when lymphocytes undergo abnormal DNA changes that cause them to grow uncontrollably. The precise triggers of these cellular mutations are not yet well understood by scientists in the general medical community.
Extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue (MALT lymphoma) is the third most common non-Hodgkin lymphoma subtype, accounting for around 6-8% of all non-Hodgkin lymphomas in the Western hemisphere.