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Acipimox (trade name Olbetam in Europe) is a niacin derivative used as a lipid-lowering agent.It reduces triglyceride levels and increases HDL cholesterol. It may have less marked adverse effects than niacin, although it is unclear whether the recommended dose is as effective as standard doses of niacin.
Atherothrombosis Intervention in Metabolic Syndrome with Low HDL/High Triglycerides: Impact on Global Health Outcomes (also known as AIM-HIGH) was a randomized control trial designed to assess the efficacy of niacin (extended-release) added to statin therapy in reducing cardiovascular events in patients with established atherosclerotic cardiovascular disease (ASCVD).
Laropiprant is a prostaglandin D2 binding drug shown to reduce niacin-induced vasodilation and flushing side effects. [ 47 ] [ 94 ] [ 95 ] A clinical trial showed no additional efficacy of Tredaptive in lowering cholesterol when used together with other statin drugs, but did show an increase in other side effects. [ 96 ]
Apples. The original source of sweetness for many of the early settlers in the United States, the sugar from an apple comes with a healthy dose of fiber.
Medical practitioners prescribe recommended doses up to 2000 mg per day of niacin in either immediate-release or slow-release formats, to lower plasma triglycerides and low-density lipiprotein cholesterol. [25] Vitamin B 5: None: No toxicity known. Vitamin B 6: US UL = 100 mg/day; EU UL = 25 mg/day: See Megavitamin-B 6 syndrome for more ...
Example of a label showing the amount of niacin (Vitamin B3), and specifying to be niacinamide in the ingredient section.. The United States Government adopted the terms niacin and niacinamide in 1942 as alternate names for nicotinic acid and nicotinamide, respectively, and encouraged their use in nontechnical contexts to avoid the public’s confusing them with the nearly unrelated (and toxic ...
The US Recommended Dietary Allowance for niacin for adult women is 14 mg/day and for adult men 16 mg/day. Niacin is available as a prescription product, either immediate release (500 mg tablets; prescribed up to 3,000 mg/day) or extended release (500 and 1,000 mg tablets; prescribed up to 2,000 mg/day).
The expanded use of colesevelam in adults with type 2 diabetes mellitus is an example of drug repositioning. [citation needed] Colesevelam is one of the bile-acid sequestrants, which along with niacin and the statins, are the three main types of cholesterol-lowering agents. The statins are considered the first-line agents.
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