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Epithelial–mesenchymal transition was first recognized as a feature of embryogenesis by Betty Hay in the 1980s. [ 1 ] [ 2 ] EMT, and its reverse process, MET ( mesenchymal-epithelial transition ) are critical for development of many tissues and organs in the developing embryo, and numerous embryonic events such as gastrulation , neural crest ...
Unlike epithelial cells – which are stationary and characterized by an apico-basal polarity with binding by a basal lamina, tight junctions, gap junctions, adherent junctions and expression of cell-cell adhesion markers such as E-cadherin, [4] mesenchymal cells do not make mature cell-cell contacts, can invade through the extracellular matrix, and express markers such as vimentin ...
Currently, three main theories have been proposed to explain the metastatic pathway of cancer: the epithelial-mesenchymal transition (EMT) and mesenchymal-epithelial transition (MET) hypothesis (1), the cancer stem cell hypothesis (2), and the macrophage–cancer cell fusion hybrid hypothesis (3).
This transition occurs through the loss of epithelial cadherin, tight junctions, and adherens junctions on the cell membranes of epithelial cells. [9] The surface molecules undergo endocytosis and the microtubule cytoskeleton loses shape, enabling mesenchyme to migrate along the extracellular matrix (ECM).
The mesothelium is a membrane composed of simple squamous epithelial cells of mesodermal origin, [2] which forms the lining of several body cavities: the pleura (pleural cavity around the lungs), peritoneum (abdominopelvic cavity including the mesentery, omenta, falciform ligament and the perimetrium) and pericardium (around the heart).
System Tissue Epithelium Subtype; circulatory: blood vessels: Simple squamous: endothelium: digestive: ducts of submandibular glands: simple columnar - digestive ...
Epithelial cell adhesion molecule (EpCAM), also known as CD326 among other names, is a transmembrane glycoprotein mediating Ca 2+-independent homotypic cell–cell adhesion in epithelia. [5] EpCAM is also involved in cell signaling, [ 6 ] migration, [ 7 ] proliferation, and differentiation. [ 8 ]
The transitional epithelium usually appears cuboidal when relaxed and squamous when stretched. [1] This tissue consists of multiple layers of epithelial cells which can contract and expand in order to adapt to the degree of distension needed. Transitional epithelium lines the organs of the urinary system and is known here as urothelium (pl ...