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The US Food and Nutrition Board has set a daily limit of 35 mg for vitamin B 3, unless under medical supervision. [1] At daily doses of nicotinic acid as low as 30 mg, flushing has been reported, always starting in the face and sometimes accompanied by skin dryness, itching, paresthesia, and headache. [23]
With a one gram dose, peak plasma concentrations of 15 to 30 μg/mL are reached within 30 to 60 minutes. Approximately 88% of an oral pharmacologic dose is eliminated by the kidneys as unchanged nicotinic acid or nicotinuric acid, its primary metabolite. The plasma elimination half-life of nicotinic acid ranges from 20 to 45 minutes. [24]
[5] [6] It is a water-soluble vitamin. Side effects are minimal. [7] [8] At high doses, liver problems may occur. [7] Normal amounts are safe for use during pregnancy. [9] Nicotinamide is in the vitamin B family of medications, specifically the vitamin B 3 complex. [10] [11] It is an amide of nicotinic acid. [7]
High levels of niacin, an essential B vitamin, ... The recommended daily allowance of niacin for men is 16 milligrams per day and for women who are not pregnant is 14 milligrams per day.
At higher doses, niacin has been used to treat high cholesterol and triglyceride levels, since it can help lower LDL (“bad”) cholesterol and raise levels of HDL (“good”) cholesterol.
Researchers with the Cleveland Clinic found having high levels of niacin, also called vitamin B3, is strongly associated with a higher chance of developing heart attack, stroke and other adverse ...
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