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Phentermine is used for a short period of time to promote weight loss, if exercise and calorie reduction are not sufficient, and in addition to exercise and calorie reduction. [5] [15] Phentermine is approved for up to 12 weeks of use and most weight loss occurs in the first weeks. [15]
If less than 3% weight loss is seen after 3 months it is recommended the medication be stopped. [3] The weight loss is modest. [ 3 ] Effects on heart related health problems or death is unclear.
A short-lived weight loss medication emerged in the 1990s with the introduction of fen-phen—the combination of fenfluramine with phentermine. Evidence linking fen-phen to valvular heart disease ...
Weight loss drugs have been developed since the early twentieth century, and many have been banned or withdrawn from the market due to adverse effects, including deaths; other drugs proved ineffective. Although many earlier drugs were stimulants such as amphetamines, in the early 2020s, GLP-1 receptor agonists became popular for weight loss.
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Fenfluramine as a single drug was first introduced in the 1970s, but was not popular because it only temporarily reduced weight. [1] A 1984 study found a weight loss of 7.5 kg on average in 24 weeks, as compared to 4.4 kg under placebo. [4] It sold modestly until the 1990s, when it was combined with phentermine and heavily marketed. [1]
Shortages of the popular weight loss medication, which belongs to a class of drugs called GLP-1s, have led to “a black market of illegal knockoffs,” said Dr. Christopher McGowan, the founder ...
A study conducted by the pharmaceutical company Smith, Kline & French (SKF) in 1947 showed that amphetamine can affect the brain center for appetite and help to reduce weight. In the late 1960s, weight reduction was the most common indication for ATS. [5] Nowadays, to suppress appetite, phentermine is still used. [2]