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Evidence suggests that it is the interaction between genes and the environment may be associated with the development of schizophrenia. [2] This is a complex process involving multiple environmental factors that have influence on a range of developmental periods that interact with a genetic susceptibility. [7]
The causes of schizophrenia that underlie the development of schizophrenia, a psychiatric disorder, are complex and not clearly understood.A number of hypotheses including the dopamine hypothesis, and the glutamate hypothesis have been put forward in an attempt to explain the link between altered brain function and the symptoms and development of schizophrenia.
About 30 to 50 percent of people with schizophrenia do not accept that they have an illness or comply with their recommended treatment. [197] For those who are unwilling or unable to take medication regularly, long-acting injections of antipsychotics may be used, [198] which reduce the risk of relapse to a greater degree than oral medications ...
"Schizophrenia is a very serious psychiatric illness, but we can do a lot to help these people function and have a normal life," said Dr. René Kahn, the head of psychiatry at Mount Sinai's Icahn ...
Still some people do recover completely and additional numbers function well in society. [5] [6] Most people with schizophrenia live independently with community support. [1] In people with a first episode of psychosis a good long-term outcome occurs in 42% of cases, an intermediate outcome in 35% of cases, and a poor outcome in 27% of cases. [7]
Schizophrenia is a debilitating and often misunderstood disorder that affects up to 1% of the world's population. [1] Although schizophrenia is a heavily studied disorder, it has remained largely impervious to scientific understanding; epigenetics offers a new avenue for research, understanding, and treatment.
People with schizophrenia are at a higher than average risk of physical ill health, and earlier death than the general population. [1] [2] [3] The fatal conditions include cardiovascular, respiratory and metabolic disorders. [4]
One related hypothesis argues that schizophrenia helps maintain charismatic leaders who utilize symptoms, such as paranoia and delusions, to create new cultures. Due to the altruistic nature of leadership, schizophrenia is selected to be maintained and bring benefits to the social group. [25]
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