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Myelin is formed by oligodendrocytes in the central nervous system and Schwann cells in the peripheral nervous system.Therefore, the first stage of myelinogenesis is often defined as the differentiation of oligodendrocyte progenitor cells (OPCs) or Schwann cell progenitors into their mature counterparts, [4] followed by myelin formation around axons.
Madhavan et al. was the first to establish a reproducible protocol that allowed for generating organoids with robust OPC and oligodendrocytes populations, and therefore myelination; they are referred to as myelin organoids, or myelinoids. [2] Timeline of small molecules & growth factors for myelinoid differentiation and generation.
The preplate also contains the predecessor to the subplate, which is sometimes referred to as a layer. As the cortical plate appears, the preplate separates into two components. The Cajal-Retzius cells go into the marginal zone, above the cortical plate, while the subplate moves inferior to the 6 cortical layers. [1]
The process of generating myelin is called myelination or myelinogenesis. In the CNS, oligodendrocyte progenitor cells (OPCs) differentiate into mature oligodendrocytes, which form myelin. In humans, myelination begins early in the 3rd trimester, [11] although only little myelin is present in either the CNS or the PNS at the time of birth ...
The myelin sheath of long nerves was discovered and named by German pathological anatomist Rudolf Virchow [21] in 1854. [22] French pathologist and anatomist Louis-Antoine Ranvier later discovered the nodes, or gaps, in the myelin sheath that now bear his name. Born in Lyon, Ranvier was one of the most prominent histologists of the
The maturation of myelination in intracortical layers coincides with critical period closure in mice, which has led to further research on the role of myelination on critical period duration. [ 37 ] Myelin is known to bind many different axonal growth inhibitors that prevent plasticity seen in critical periods. [ 38 ]
Spontaneous myelin repair was first observed in cat models. [49] It was later discovered to occur in the human CNS as well, specifically in cases of multiple sclerosis (MS). [50] Spontaneous myelin repair does not result in morphologically normal oligodendrocytes and is associated with thinner myelin compared to axonal diameter than normal ...
For example, mice undergo cortical neurogenesis from about embryonic day (post-conceptional day) (E)11 to E17, and are born at about E19.5. [9] Ferrets are born at E42, although their period of cortical neurogenesis does not end until a few days after birth. [10]