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A calibration curve plot showing limit of detection (LOD), limit of quantification (LOQ), dynamic range, and limit of linearity (LOL).. In analytical chemistry, a calibration curve, also known as a standard curve, is a general method for determining the concentration of a substance in an unknown sample by comparing the unknown to a set of standard samples of known concentration. [1]
The instrument detection limit (IDL) is the analyte concentration that is required to produce a signal greater than three times the standard deviation of the noise level. This may be practically measured by analyzing 8 or more standards at the estimated IDL then calculating the standard deviation from the measured concentrations of those standards.
Algorithms for calculating variance play a major role in computational statistics.A key difficulty in the design of good algorithms for this problem is that formulas for the variance may involve sums of squares, which can lead to numerical instability as well as to arithmetic overflow when dealing with large values.
Since the sample mean and variance are independent, and the sum of normally distributed variables is also normal, we get that: ^ + ˙ (+, + ()) Based on the above, standard confidence intervals for + can be constructed (using a Pivotal quantity) as: ^ + + And since confidence intervals are preserved for monotonic transformations, we get that
In statistics, deviance is a goodness-of-fit statistic for a statistical model; it is often used for statistical hypothesis testing.It is a generalization of the idea of using the sum of squares of residuals (SSR) in ordinary least squares to cases where model-fitting is achieved by maximum likelihood.
which is an unbiased estimator of the variance of the mean in terms of the observed sample variance and known quantities. If the autocorrelations are identically zero, this expression reduces to the well-known result for the variance of the mean for independent data. The effect of the expectation operator in these expressions is that the ...
Firstly, if the true population mean is unknown, then the sample variance (which uses the sample mean in place of the true mean) is a biased estimator: it underestimates the variance by a factor of (n − 1) / n; correcting this factor, resulting in the sum of squared deviations about the sample mean divided by n-1 instead of n, is called ...
The variance of randomly generated points within a unit square can be reduced through a stratification process. In mathematics , more specifically in the theory of Monte Carlo methods , variance reduction is a procedure used to increase the precision of the estimates obtained for a given simulation or computational effort. [ 1 ]