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Cholera (/ ˈ k ɒ l ər ə /) is an infection of the small intestine by some strains of the bacterium Vibrio cholerae. [4] [3] Symptoms may range from none, to mild, to severe. [3]The classic symptom is large amounts of watery diarrhea lasting a few days. [2]
The bacterium as the cause of cholera was discovered by Robert Koch in 1884. Sambhu Nath De isolated the cholera toxin and demonstrated the toxin as the cause of cholera in 1959. The bacterium has a flagellum (a tail like structure) at one pole and several pili throughout its cell surface. It undergoes respiratory and fermentative metabolism.
Preceding the 1854 Broad Street cholera outbreak, physicians and scientists held two competing theories on the causes of cholera in the human body: miasma theory and germ theory. [6] The London medical community debated between these causes for the persistent cholera outbreaks in the city.
Cholera autoinducer-1 (CAI-1) is an autoinducer signaling molecule present in the bacterium Vibrio cholerae, which causes cholera. CAI-1 is known structurally as a (S)-3-hydroxytridecan and regulates expression of virulence factors.
During the second cholera pandemic of 1816–1837, the scientific community varied in its beliefs about its causes. In France, doctors believed cholera was associated with the poverty of certain communities or poor environment. Russians believed the disease was contagious and quarantined their citizens.
Cholera toxin (also known as choleragen and sometimes abbreviated to CTX, Ctx or CT) is an AB5 multimeric protein complex secreted by the bacterium Vibrio cholerae. [ 1 ] [ 2 ] CTX is responsible for the massive, watery diarrhea characteristic of cholera infection. [ 3 ]
Dozens of escaped residents of the besieged town of al-Hilaliya in Sudan's El Gezira state have tested positive for cholera, a medical source told Reuters, in a development that provides a likely ...
Cholera broke out 27 times during the hajj at Mecca from the 19th century to 1930. [58] The sixth pandemic killed more than 800,000 in India. [12] The 1902–1904 cholera epidemic claimed 200,000 lives in the Philippines, [59] including their revolutionary hero and first prime minister Apolinario Mabini. A 1905 governmental report mentioned he ...