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Corticotropin-releasing hormone (CRH) (also known as corticotropin-releasing factor (CRF) or corticoliberin; corticotropin may also be spelled corticotrophin) is a peptide hormone involved in stress responses. It is a releasing hormone that belongs to corticotropin-releasing factor family. In humans, it is encoded by the CRH gene. [5]
The introduction of CRH series was a major part of the sixth national railway speedup, implemented on April 18, 2007. [1] By the end of 2020, China Railway High-speed provided service to all provinces in China , and operated just under 38,000 km (24,000 mi) passenger tracks in length, accounting for about two-thirds of the world's high-speed ...
Corticotropin-releasing hormone binding protein (CRH-BP) binds corticotropin-releasing hormone and several related peptide hormones (urocortin 1, urotensin 1, and sauvagine). [1] It is an ancient, highly conserved protein whose origin predates the divergence of protostomes and deuterostomes .
CRH is evolutionary-related to a number of other active peptides. Urocortin acts in vitro to stimulate the secretion of adrenocorticotropic hormone . Urotensin is found in the teleost caudal neurosecretory system and may play a role in osmoregulation and as a corticotropin-releasing factor.
The trainset with series number CRH 380A-6001 reached the maximum speed of 416.6 km/h (258.9 mph). [ 17 ] CRH380A entered service on September 30, 2010 in limited capacity to handle National Day traffic demand on the Shanghai–Nanjing high-speed railway line.
Corticotropin-releasing hormone receptors (CRHRs), also known as corticotropin-releasing factor receptors (CRFRs) are a G protein-coupled receptor family that binds corticotropin-releasing hormone (CRH). [1] There are two receptors in the family, designated as type 1 and 2, each encoded by a separate gene (CRHR1 and CRHR2 respectively).
In contrast, CRHR2 alpha contains a unique pseudo signal peptide that is not removed from the mature receptor. In adenylate cyclase activation assays, CRH-related peptides are 10 times more potent at stimulating CRHR2 beta than CRHR2 alpha and CRHR2 gamma, suggesting that the N-terminal sequence is involved in the ligand-receptor interaction. [9]
The human CRHR1 gene contains 14 exons over 20 kb of DNA, and its full gene product is a peptide composed of 444 amino acids. [7] Excision of exon 6 yields in the mRNA for the primary functional CRF 1, [7] which is a peptide composed of 415 amino acids, arranged in seven hydrophobic alpha-helices.