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Intravenous iron therapy has an established role in the treatment of iron deficiency anaemia when oral supplements are ineffective or cannot be used. [12] IV iron infusions can administer the exact dose of iron to normalise levels in the blood. [7] Pre-operative anaemia is associated with high risk of death.
Iron preparation is the formulation for iron supplements indicated in prophylaxis and treatment of iron-deficiency anemia. Examples of iron preparation include ferrous sulfate, ferrous gluconate, and ferrous fumarate. It can be administered orally, and by intravenous injection, or intramuscular injection. [1] Early Iron Supplement for Anemia
Sodium ferric gluconate complex, sold under the brand name Ferrlecit, is an intravenously administered iron medication for the treatment of iron deficiency anemia in adults and in children aged six years and older with chronic kidney disease receiving hemodialysis who are receiving supplemental epoetin therapy. [2]
Overall, hemoglobin was 0.71g/dl higher than those treated with oral iron supplements. Iron stores in the liver, estimated by serum ferritin, were also 224.84 μg/L higher in those receiving IV-iron. [58] However, there was also low-certainty evidence that allergic reactions were more likely following IV-iron therapy.
The iron is then either stored for later use in the body or taken up by plasma. The plasma transfers the iron to hemoglobin, where it can begin increasing erythropoiesis (red blood cell production). [3] Iron sucrose is most commonly used to treat iron deficiency anemia, which can be caused by chronic kidney disease. [3]
Approximately, 200 to 250 mg of iron is transfused per unit of blood. [4] [5] Iron overloading is resulted because human body cannot excrete excess iron from frequent transfusions, leading to accumulation of iron in blood. [4] [9] Iron in blood causes damage to important organs, such as the heart, liver, bone tissue and endocrine glands.
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