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Permethrin is a medication and an insecticide. [6] [7] As a medication, it is used to treat scabies and lice. [8]It is applied to the skin as a cream or lotion. [6] As an insecticide, it can be sprayed onto outer clothing or mosquito nets to kill the insects that touch them.
In 2022, the most comprehensive study of pharmaceutical pollution of the world's rivers found that it threatens "environmental and/or human health in more than a quarter of the studied locations". It investigated 1,052 sampling sites along 258 rivers in 104 countries, representing the river pollution of 470 million people.
The World Health Organization published in 2004 that "Prallethrin is of low mammalian toxicity, with no evidence of carcinogenicity" and "is very toxic to bees and fish but of low toxicity to birds." [2] Prallethrin is a member of the pyrethroid class of insecticides. Pyrethroids have historically been classified into two groups, Type I and ...
Scabies (/ ˈ s k eɪ b iː z, ˈ s k eɪ b i iː z /; [10] also sometimes known as the seven-year itch) [1] is a contagious human skin infestation by the tiny (0.2–0.45 mm) mite Sarcoptes scabiei, [1] [3] variety hominis. The word is from Latin: scabere, lit. 'to scratch'. [11] The most common symptoms are severe itchiness and a pimple-like ...
Benzyl benzoate is an effective and inexpensive topical treatment for human scabies. [7] It has vasodilating and spasmolytic effects and is present in many asthma and whooping cough drugs. [ 8 ] It is also used as an excipient in some testosterone -replacement medications (like Nebido ) for treating hypogonadism .
Deltamethrin is a pyrethroid composed of a single stereoisomer, of a possible 8 stereoisomers, selectively prepared by the esterification of (1R,3R)- or cis-2,2-dimethyl-3-(2,2-dibromovinyl)cyclopropanecarboxylic acid with (alpha,S)- or (+)-alpha-cyano-3-phenoxybenzyl alcohol or by selective recrystallization of the racemic esters obtained by esterification of the (1R,3R)- or cis-acid with the ...
In humans, cypermethrin is deactivated by enzymatic hydrolysis to several carboxylic acid metabolites, which are eliminated in the urine. Worker exposure to the chemical can be monitored by measurement of the urinary metabolites, while severe overdosage may be confirmed by quantitation of cypermethrin in blood or plasma.
The pyrethroids with an α-cyanogroup block the sodium-channel permanently, causing the membrane to be permanently hyperpolarized. The resting potential will not be restored, and no further action potential can be generated. The pyrethroids without an α-cyanogroup, to which bifenthrin belongs, are only able to bind to the sodium channel ...
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