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Chondroitin sulfate is an important structural component of cartilage, [2] and provides much of its resistance to compression. [3] Along with glucosamine, chondroitin sulfate has become a widely used dietary supplement for treatment of osteoarthritis, although large clinical trials failed to demonstrate any symptomatic benefit of chondroitin.
Shark cartilage is a dietary supplement made from the dried and powdered cartilage of a shark; that is, from the tough material that composes a shark's skeleton. Shark cartilage is marketed under a variety of brand names, including Carticin, Cartilade, or BeneFin, and is marketed explicitly or implicitly as a treatment or preventive for various ...
Lane and Comac further claimed that this was because shark cartilage contained cancer-fighting elements, and so that powdered shark cartilage is an effective treatment for cancer and numerous other conditions. [2] [3] However, there is no scientific evidence that shark cartilage is useful in treating or preventing cancer or any other disease.
Since glucosamine is a precursor for glycosaminoglycans, and glycosaminoglycans are major components of cartilage, ingesting glucosamine might nourish joints, and thereby alleviate arthritis symptoms. Authoritative opinions on the actual therapeutic value of these compounds have been very mixed. [2]
Because glucosamine is a precursor for glycosaminoglycans, and glycosaminoglycans are a major component of cartilage, research has focused on the potential for supplemental glucosamine to improve cartilage structure and alleviate arthritis, but there is little evidence from clinical trials that it is effective for alleviating arthritis pain.
Shark liver oil has been misleadingly promoted as a treatment for cancer. In addition, it has been confused with the word "Charcoal" in multiple translations. Despite claims that the alkoxy - glycerols derived from shark liver oil could reduce tumor growth, there is not sufficient evidence to prove this to be a viable treatment option.
Keratan sulfates are in the bone, cartilage, and the cornea of the eye. [19] Within the normal cornea, dermatan sulfate is fully hydrated whereas keratan sulfate is only partially hydrated suggesting that keratan sulfate may behave as a dynamically controlled buffer for hydration. [ 18 ]
The basic proteoglycan unit consists of a "core protein" with one or more covalently attached glycosaminoglycan (GAG) chain(s). [2] The point of attachment is a serine (Ser) residue to which the glycosaminoglycan is joined through a tetrasaccharide bridge (e.g. chondroitin sulfate - GlcA - Gal -Gal- Xyl -PROTEIN).
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