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The spiral (cochlear) ganglion is a group of neuron cell bodies in the modiolus, the conical central axis of the cochlea. These bipolar neurons innervate the hair cells of the organ of Corti . They project their axons to the ventral and dorsal cochlear nuclei as the cochlear nerve , a branch of the vestibulocochlear nerve (CN VIII).
Acoustic trauma occurs when a continuous transient sounds transfers enough energy to a cochlea to result in necrosis of the outer hair cells (OHC), inner hair cells (IHC), and cause glutamate excitotoxicity of first-order afferent neurons of the spiral ganglion (cochlear synaptopathy). This can occur when an impact or impulse sound like an ...
The cochlear nerve travels away from the cochlea of the inner ear where it starts as the spiral ganglia. Processes from the organ of Corti conduct afferent transmission to the spiral ganglia. It is the inner hair cells of the organ of Corti that are responsible for activation of afferent receptors in response to pressure waves reaching the ...
However, the neonatal mouse cochlea can, to a limited extent, replace damaged or lost hair cells. [24] Hair cell restoration can occur by direct transdifferentiation and mitotic regeneration. Mitotic division occurs when a supporting cell first divides and, subsequently, one or both daughter cells ( cytokinesis ) becomes a hair cell.
The cell bodies of the cochlear nerve lie within the cochlea and collectively form the spiral ganglion, named for the spiral shape it shares with the cochlea. These central axons exit the cochlea at its base and form a nerve trunk , which, in humans, is approximately one inch long.
Auditory neuropathy (AN) is a hearing disorder in which the outer hair cells of the cochlea are present and functional, but sound information is not transmitted sufficiently by the auditory nerve to the brain. The cause may be several dysfunctions of the inner hair cells of the cochlea or spiral ganglion neuron levels. [1]
The vestibular nerve is one of the two branches of the vestibulocochlear nerve (the cochlear nerve being the other). In humans the vestibular nerve transmits sensory information from vestibular hair cells located in the two otolith organs (the utricle and the saccule) and the three semicircular canals via the vestibular ganglion of Scarpa.
A vestibular neurectomy is an operation that severs the vestibular nerve, which contributes to balance, while sparing the cochlear nerve, which contributes to hearing. The procedure has the potential to relieve vertigo, but may preserve the ability to hear. [7] It is important to note that this procedure will not reverse the effects of deafness.