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A consensus logo is a simplified variation of a sequence logo that can be embedded in text format. Like a sequence logo, a consensus logo is created from a collection of aligned protein or DNA/RNA sequences and conveys information about the conservation of each position of a sequence motif or sequence alignment [1] [4].
The score is greater than 0 if it is more likely to be a functional site than a random site, and less than 0 if it is more likely to be a random site than a functional site. [1] The sequence score can also be interpreted in a physical framework as the binding energy for that sequence.
In biology, a sequence motif is a nucleotide or amino-acid sequence pattern that is widespread and usually assumed to be related to biological function of the macromolecule. For example, an N -glycosylation site motif can be defined as Asn, followed by anything but Pro, followed by either Ser or Thr, followed by anything but Pro residue .
And it is not possible to write it as a single consensus sequence e.g. ACNCCA. An alternative method of representing a consensus sequence uses a sequence logo. This is a graphical representation of the consensus sequence, in which the size of a symbol is related to the frequency that a given nucleotide (or amino acid) occurs at a certain position.
A sequence logo for the LexA-binding motif of gram-positive bacteria. As the adenosine at position 5 is highly conserved, it appears larger than other characters. [29] Multiple sequence alignments can be used to visualise conserved sequences.
For instance, encoding the ASCII character "0" can be viewed as 10011101100, where a sequence of 1's is a bar and a sequence of 0's is a space. A single 1 would be the thinnest line in the bar code. Three 1's in sequence (111) indicates a bar three times as thick as a single 1 bar.
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[1] [2] It is a cloud-based data storage and analysis platform developed at the Centre for Biodiversity Genomics in Canada. It consists of four main modules, a data portal, an educational portal, a registry of BINs (putative species), and a data collection and analysis workbench which provides an online platform for analyzing DNA sequences . [ 2 ]