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The glomerular basement membrane of the kidney is the basal lamina layer of the glomerulus.The glomerular endothelial cells, the glomerular basement membrane, and the filtration slits between the podocytes perform the filtration function of the glomerulus, separating the blood in the capillaries from the filtrate that forms in Bowman's capsule. [1]
The basal lamina of the filtration barrier is composed of three layers. The first layer is the lamina rara externa, adjacent to the podocyte processes. The second layer is the lamina rara interna, adjacent to the endothelial cells. The final layer is the lamina densa which is a darker central zone of the basal lamina.
B. Glomerular basement membrane: 1. lamina rara interna 2. lamina densa 3. lamina rara externa C. Podocytes: 1. enzymatic and structural protein 2. filtration slit 3. diaphragma. Podocytes have primary processes called trabeculae, which wrap around the glomerular capillaries. [2]
The basal lamina is composed of 3 layers: lamina rara externa, lamina densa, and lamina rara interna. The lamina rara externa is adjacent to the podocyte processes. The lamina densa is the central layer consisting of type IV collagen and laminin. This layer acts as a selective macromolecular filter, preventing the passage of large protein ...
The basal lamina is made and maintained by the cells that sit on it. It acts as a point of attachment for cells. However, it can also have other function such as a permeability barrier in the glomerulus (urine production). Some of the matrix molecules (of the basal lamina) mediate synaptic adhesion in neuromuscular synapses. [8]
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Nuclear lamins interact with inner nuclear membrane proteins to form the nuclear lamina on the interior of the nuclear envelope. Lamins have elastic and mechanosensitive properties, and can alter gene regulation in a feedback response to mechanical cues. [1] Lamins are present in all animals but are not found in microorganisms, plants or fungi.
External lamina is a structure similar to basal lamina that surrounds the sarcolemma of muscle cells. It is secreted by myocytes and consists primarily of Collagen type IV, laminin and perlecan (heparan sulfate proteoglycan). Nerve cells, including perineurial cells and Schwann cells also have an external lamina-like protective coating. [1]