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In organic chemistry, the Schmidt reaction is an organic reaction in which an azide reacts with a carbonyl derivative, usually an aldehyde, ketone, or carboxylic acid, under acidic conditions to give an amine or amide, with expulsion of nitrogen.
Because primary and secondary amines react with aldehydes and ketones, the most common variety of these aminocarbonyl compounds feature tertiary amines. Such compounds are produced by amination of α-haloketones and α-haloaldehydes. [1] Examples include cathinones, methadone, molindone, pimeclone, ferruginine, and tropinone.
The Leuckart reaction is the chemical reaction that converts aldehydes or ketones to amines. The reaction is an example of reductive amination. [1] The reaction, named after Rudolf Leuckart, uses either ammonium formate or formamide as the nitrogen donor and reducing agent. It requires high temperatures, usually between 120 and 130 °C; for the ...
The Gewald reaction (or the Gewald aminothiophene synthesis) is an organic reaction involving the condensation of a ketone (or aldehyde when R 2 = H) with a α-cyanoester in the presence of elemental sulfur and base to give a poly-substituted 2-amino-thiophene. [1] [2] The Gewald reaction. The reaction is named after the German chemist Karl ...
For these latter reactions, two equivalents of the incoming group add to form an alcohol rather than a ketone or aldehyde. This occurs even if the equivalents of nucleophile are closely controlled. Overaddition of nucleophiles. The Weinreb–Nahm amide has since been adopted into regular use by organic chemists as a dependable method for the ...
The reaction was discovered by Teruaki Mukaiyama in 1973. [2] His choice of reactants allows for a crossed aldol reaction between an aldehyde and a ketone (>C=O), or a different aldehyde without self-condensation of the aldehyde. For this reason the reaction is used extensively in organic synthesis.
The Henry reaction is a classic carbon–carbon bond formation reaction in organic chemistry. Discovered in 1895 by the Belgian chemist Louis Henry (1834–1913), it is the combination of a nitroalkane and an aldehyde or ketone in the presence of a base to form β-nitro alcohols.
The Benary reaction is an organic reaction.In 1931 Erich Bénary [1] [2] discovered that β-(N,N-dialkylamino)-vinyl ketones reacted with Grignard reagents in a 1,4-addition to give α,β-unsaturated ketones, α,β-unsaturated aldehydes and α,β-unsaturated esters as well as poly-unsaturated ketones and aldehydes [3] after hydrolysis of the reaction intermediate and elimination of a ...