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The reuptake effects of venlafaxine are dose-dependent. At low doses (<150 mg/day), it acts only on serotonergic transmission. At moderate doses (>150 mg/day), it acts on serotonergic and noradrenergic systems, whereas at high doses (>300 mg/day), it also affects dopaminergic neurotransmission. [22]
The National Institute for Clinical and Health Excellence recommends (as of September 2013) that duloxetine not be routinely offered as first-line treatment, and that it only be offered as second-line therapy in women wishing to avoid therapy. The guideline further states that women should be counseled regarding the drug's side effects. [53]
The results highlight the importance of discussing antidepressant side effects and medication adherence with individuals taking these medications. Comparing 8 antidepressants’ effects on weight
Thousands of bottles of the antidepressant duloxetine, which is the generic version of Cymbalta, have been recalled due to the presence of a toxic chemical, according to a notice from the Food and ...
Intimate side effects like ED are known to occur with many antidepressants, including the following common medications: Citalopram (generic for Celexa) Sertraline (Zoloft)
Additionally, some clinically used drugs such as chlorpheniramine, dextromethorphan, and methadone possess SRI properties secondarily to their primary mechanism of action(s) and this contributes to their side effect and drug interaction profiles. A closely related type of drug is a serotonin releasing agent (SRA), an example of which is ...
Some side effects, such as weight gain, occur more frequently with certain types of antidepressant medication. Switching to a new type of antidepressant may help reverse any weight gain you’ve ...
The range of possible mechanisms includes (1) nonspecific neurological effects (e.g., sedation) that globally impair behavior including sexual function; (2) specific effects on brain systems mediating sexual function; (3) specific effects on peripheral tissues and organs, such as the penis, that mediate sexual function; and (4) direct or ...