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Miglitol is an oral alpha-glucosidase inhibitor used in the treatment of type 2 diabetes. It works by reversibly inhibiting alpha-glucosidase enzymes in the small intestine, which delays the digestion of complex carbohydrates and subsequently reduces postprandial glucose levels. [ 1 ]
Acarbose degradation is the unique feature of glycoside hydrolases in gut microbiota, acarbose degrading glucosidase, which hydrolyze acarbose into an acarviosine-glucose and glucose. [17] Human enzymes do transform acarbose: the pancreatic alpha-amylase is able to perform a rearrangement reaction , moving the glucose unit in the "tail" maltose ...
Absorption is strongly correlated with openness to experience. [6] Studies using factor analysis have suggested that the fantasy, aesthetics, and feelings facets of the NEO PI-R Openness to Experience scale are closely related to absorption and predict hypnotisability, whereas the remaining three facet scales of ideas, actions, and values are largely unrelated to these constructs. [5]
The pharmacological definition cannot apply to these substances because utilization and absorption is a function of the nutritional status and physiological state of the subject, [10] resulting in even greater differences from individual to individual (inter-individual variation). Therefore, bioavailability for dietary supplements can be ...
Clinical studies are often very specific, typically beginning with animal testing and ending with human testing. In the human testing phase, there is often a group of subjects: one group is given a placebo, and the other is administered a carefully measured therapeutic dose of the drug in question.
Absorption is the journey of a drug travelling from the site of administration to the site of action. [ 1 ] [ 2 ] The drug travels by some route of administration ( oral , topical-dermal , etc.) in a chosen dosage form (e.g., tablets , capsules , or in solution ). [ 3 ]
Photo: Shutterstock. Design: Eat This, Not That!The battle of the diets—low-fat versus low-carb—has been a hot topic in the world of health and nutrition for ages. Low-fat diets focus on ...
The Chinese definition of "bioequivalence" entails having the test drug's geometric mean C max, AUC (0–t), and AUC (0–∞) fall into 80%–125% of the reference drug in both fasting and fed states. The reference drug should be preferably the original brand-name drug, then (if not available) an internationally-recognized generic approved by ...