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cAMP represented in three ways Adenosine triphosphate. Cyclic adenosine monophosphate (cAMP, cyclic AMP, or 3',5'-cyclic adenosine monophosphate) is a second messenger, or cellular signal occurring within cells, that is important in many biological processes. cAMP is a derivative of adenosine triphosphate (ATP) and used for intracellular signal transduction in many different organisms ...
Cyclic AMP receptors from slime molds are a distinct family of G-protein coupled receptors.These receptors control development in Dictyostelium discoideum. In D. discoideum, the cyclic AMP receptors coordinate aggregation of individual cells into a multicellular organism, and regulate the expression of a large number of developmentally-regulated genes.
The signal to activate CRP is the binding of cyclic AMP. Binding of cAMP to CRP leads to a long-distance signal transduction from the N-terminal cAMP-binding domain to the C-terminal domain of the protein, which is responsible for interaction with specific sequences of DNA.
11910 Ensembl ENSG00000162772 ENSMUSG00000026628 UniProt P18847 Q60765 RefSeq (mRNA) NM_001030287 NM_001040619 NM_001206484 NM_001206485 NM_001206486 NM_001206488 NM_001674 NM_004024 NM_007498 RefSeq (protein) NP_001025458 NP_001035709 NP_001193413 NP_001193415 NP_001193417 NP_001665 NP_031524 Location (UCSC) Chr 1: 212.57 – 212.62 Mb Chr 1: 190.9 – 190.95 Mb PubMed search Wikidata View ...
In a cAMP-dependent pathway, the activated G s alpha subunit binds to and activates an enzyme called adenylyl cyclase, which, in turn, catalyzes the conversion of ATP into cyclic adenosine monophosphate (cAMP). [5] Increases in concentration of the second messenger cAMP may lead to the activation of cyclic nucleotide-gated ion channels [6]
Examples of second messenger molecules include cyclic AMP, cyclic GMP, inositol triphosphate, diacylglycerol, and calcium. [2] First messengers are extracellular factors, often hormones or neurotransmitters, such as epinephrine, growth hormone, and serotonin.
PDBe-KB provides an overview of all the structure information available in the PDB for Human Cyclic AMP-dependent transcription factor ATF-4 ATF4 (activating transcription factor 4) This article incorporates text from the United States National Library of Medicine , which is in the public domain .
8-Bromoadenosine 3',5'-cyclic adenosine monophosphate (8-Br-cAMP) is a brominated derivative of cyclic adenosine monophosphate (cAMP). 8-Br-cAMP is an activator of cyclic AMP-dependent protein kinase, and it is long-acting because it is resistant to degradation by cyclic AMP phosphodiesterase.