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Of these, streptomycin and neomycin found extensive application in the treatment of numerous infectious diseases. Streptomycin was the first antibiotic cure for tuberculosis (TB). In 1952 Waksman was the recipient of the Nobel Prize in Physiology or Medicine in recognition "for his discovery of streptomycin, the first antibiotic active against ...
Amphotericin B was isolated from Streptomyces nodosus in 1955 at the Squibb For Medical Research Institute from cultures isolated from the streptomycete obtained from the river bed of Orinoco in that region of Venezuela [6] and came into medical use in 1958. [7] [8] It is on the World Health Organization's List of Essential Medicines. [9]
Novobiocin, also known as albamycin, is an aminocoumarin antibiotic that is produced by the actinomycete Streptomyces niveus, which has recently been identified as a subjective synonym for S. spheroides [1] a member of the class Actinomycetia. Other aminocoumarin antibiotics include clorobiocin and coumermycin A1. [2]
Actinomycosis is a rare infectious bacterial disease caused by the gram-positive Actinomyces species. [1] The name refers to ray-like appearance of the organisms in the granules.
Streptomyces is the largest genus of Actinomycetota, and the type genus of the family Streptomycetaceae. [3] Over 700 species of Streptomyces bacteria have been described. [ 4 ] [ 5 ] [ 6 ] As with the other Actinomycetota, streptomycetes are gram-positive , and have very large genomes with high GC content .
Streptomyces isolates have yielded the majority of human, animal, and agricultural antibiotics, as well as a number of fundamental chemotherapy medicines. Streptomyces is the largest antibiotic -producing genus of Actinomycetota , producing chemotherapy, antibacterial, antifungal , antiparasitic drugs, and immunosuppressants . [ 1 ]
Streptomyces antibioticus (previously known as Actinomyces antibioticus) is a gram-positive bacterium discovered in 1941 by Nobel-prize-winner Selman Waksman and H. Boyd Woodruff. [ 1 ] [ 2 ] Its name is derived from the Greek "strepto-" meaning "twisted", alluding to this genus ' chain-like spore production, [ 3 ] and " antibioticus ...
Bafilomycin A1, B1 and C1 were first isolated from Streptomyces griseus in 1983. [11] During a screen seeking to identify microbial secondary metabolites whose activity mimicked that of two cardiac glycosides, bafilomycin C1 was identified as an inhibitor of P-ATPase with a k i of 11 μM.