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An antral or secondary follicle, also known as Graafian follicle and tertiary follicle, is an ovarian follicle during a certain latter stage of folliculogenesis. Definitions differ in where the shift into an antral follicle occurs in the staging of folliculogenesis, with some stating that it occurs when entering the secondary stage, [ 1 ] and ...
CCs primarily support growth and development of the oocyte whereas MGCs primarily serve an endocrine function and support the growth of the follicle. Cumulus cells aid in oocyte development and show higher expression of SLC38A3, a transporter for amino acids, and Aldoa, Eno1, Ldh1, Pfkp, Pkm2, and Tpi1, enzymes responsible for glycolysis. [ 7 ]
Histology image: 18404loa – Histology Learning System at Boston University - "Female Reproductive System: ovary, cumulus oophorus" Histology image: 14808loa – Histology Learning System at Boston University - "Female Reproductive System: ovary, membrana granulosa" Histology image: 83_15 at the University of Oklahoma Health Sciences Center
This remaining follicle, called the dominant follicle, will grow quickly and dramatically—up to 20 mm in diameter—to become the preovulatory follicle. Note: Many sources misrepresent the pace of follicle growth, some even suggesting that it takes only fourteen days for a primordial follicle to become preovulatory.
[citation needed] It is formed by follicle cells adhering to the oocyte before it leaves the ovarian follicle, and originates from the squamous granulosa cells present at the primordial stage of follicular development.
"The tertiary follicle, also known as a Graafian follicle or antral follicle, is marked by the formation of a fluid-filled cavity adjacent to the oocyte called the antrum." Furthermore, according to < Junqueira's Basic Histology: Text & Atlas, 12e > the secondary follicle is also called an antral follicle, not the tertiary, as stated in the ...
An ovarian follicle is a roughly spheroid cellular aggregation set found in the ovaries. It secretes hormones that influence stages of the menstrual cycle . At the time of puberty , women have approximately 200,000 to 300,000 follicles, [ 1 ] [ 2 ] each with the potential to release an egg cell (ovum) at ovulation for fertilization . [ 3 ]
As the follicle matures, the area between the follicle and the ovarian surface begins to thin and weaken under the influence of the luteinizing hormone and local cytokines. At ovulation the stigma ruptures and the secondary oocyte is released along with surrounding granulosa cells, from the region of the cumulus oophorus, and follicular fluid.