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About 60% of the metronidazole is metabolized by oxidation to the main metabolite hydroxymetronidazole and a carboxylic acid derivative, and by glucuronidation. The metabolites show antibiotic and antiprotozoal activity in vitro. [62] Metronidazole and its metabolites are mainly excreted via the kidneys (77%) and to a lesser extent via the ...
[1] [2] [8] [6] Difficulties in gastrointestinal absorption caused by pH, enzymatic activity and drug-food interactions can be minimized, while at the same time avoiding GI irritation. [ 1 ] [ 2 ] [ 6 ] The topical dosage form allows stable and continuous drug delivery to the site of application, [ 2 ] while having a faster drug release than ...
Currently, the desired family size for women in Bangladesh is 2.2 children, which has slightly decreased from 2.4 children over the past decade. Of all pregnancies, 74% were wanted or intended, while 26% were unintended. This includes 15% that were mistimed and 11% that were unwanted.
metronidazole 500–750 mg three times a day for 5–10 days; tinidazole 2g once a day for 3 days is an alternative to metronidazole; Doses for children are calculated by body weight and a pharmacist should be consulted for help.
A common saying that a woman "is eating for two" while pregnant implies that a mother should consume twice as much during pregnancy, but is misleading. Although maternal consumption will directly affect both herself and the growing fetus , overeating excessively will compromise the baby's health as the infant will have to work extra hard to ...
While most medications on the list are available as generic products, being under patent does not preclude inclusion. [7] The first list was published in 1977 and included 208 medications. [8] [2] [9] The WHO updates the list every two years. [10]
Feet of a baby born to a mother who had taken thalidomide while pregnant. In the late 1950s and early 1960s, the use of thalidomide in 46 countries was prescribed to women who were pregnant or who subsequently became pregnant, and consequently resulted in the "biggest anthropogenic medical disaster ever," with more than 10,000 children born with a range of severe deformities, such as ...
Use in pregnancy is believed to be safe for the baby. [4] Miconazole is in the imidazole family of medications. [2] It works by decreasing the ability of fungi to make ergosterol, an important part of their cell membrane. [2] Miconazole was patented in 1968 and approved for medical use in 1971. [5]