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It is a combination of two previously existing medications: dutasteride, brand name Avodart, and tamsulosin, brand name Flomax. It contains 0.5 mg of dutasteride and 0.4 mg of tamsulosin hydrochloride. [2] Jalyn was the result of the CombAT (Combination of Avodart and Tamsulosin) trial of 2008.
Dutasteride is approved for the treatment of male androgenetic alopecia in South Korea and Japan at a dosage of 0.5 mg per day. [6] [17] Several studies have found it to induce hair regrowth in men more rapidly and to a greater extent than even the highest approved dosage of finasteride.
Finasteride is most effective on the crown but can reduce hair loss in all areas of the scalp. [27] [28] Finasteride has also been tested for pattern hair loss in women; however, the results were no better than placebo. [29] Finasteride is less effective in the treatment of scalp hair loss than dutasteride. [30] [31]
One study from 2006 compared the effects of finasteride and dutasteride on 416 men between 21 to 45 years old who received either dutasteride, finasteride or a placebo treatment.
Finasteride is one of two 5-alpha reductase inhibitors, along with dutasteride. 5-alpha reductase is an enzyme that your body eventually converts into a hormone called dihydrotestosterone (DHT).
Oral Finasteride vs Topical Finasteride. ... There’s another 5-alpha-reductase inhibitor called dutasteride that’s also FDA-approved to treat the symptoms of BPH, but is sometimes used off ...
Dutasteride was approved for the treatment of BPH in 2001 and was subsequently approved for pattern hair loss in South Korea in 2009 and in Japan in 2015. [ 44 ] [ 45 ] The patent protection on finasteride and dutasteride has expired and both drugs are available as generic medications .
Tamsulosin is a selective α 1 receptor antagonist that has preferential selectivity for the α 1A receptor in the prostate versus the α 1B receptor in the blood vessels. [ 25 ] When alpha 1 receptors in the bladder neck, prostate, ureter, and urethra are blocked, a relaxation in smooth muscle tissue results. [ 16 ]
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