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Aromatase excess syndrome (AES or AEXS) is a rarely diagnosed genetic and endocrine syndrome which is characterized by an overexpression of aromatase, the enzyme responsible for the biosynthesis of the estrogen sex hormones from the androgens, in turn resulting in excessive levels of circulating estrogens and, accordingly, symptoms of hyperestrogenism.
Signs of hyperestrogenism may include heightened levels of one or more of the estrogen sex hormones (usually estradiol and/or estrone), lowered levels of follicle-stimulating hormone and/or luteinizing hormone (due to suppression of the hypothalamic–pituitary–gonadal axis by estrogen), and lowered levels of androgens such as testosterone (generally only relevant to males). [1]
However, in a study of transgender men who are using TRT as part of their medical transition, 5 to 17 percent were found to develop some hair loss in their first year of TRT.
Androgen replacement therapy (ART), often referred to as testosterone replacement therapy (TRT), is a form of hormone therapy in which androgens, often testosterone, are supplemented or replaced. It typically involves the administration of testosterone through injections, skin creams, patches, gels, pills, or subcutaneous pellets.
One study concluded that long-term testosterone replacement therapy (TRT) in middle-aged men with late-onset hypogonadism (LOH) and metabolic syndrome (MS) led to a significant increase in both vertebral and femoral bone mineral density (BMD) after 36 months of treatment, as measured by dual-energy x-ray absorptiometry. The TRT treatment was ...
The discovery of testosterone in 1935 led to the development of testosterone replacement therapy (TRT), which has since become a cornerstone treatment for male hypogonadism. Additionally, hormone replacement therapy (HRT) for women has advanced, providing solutions for conditions such as menopause-related hypogonadism. [ 9 ]
Estradiol (E2) is a medication and naturally occurring steroid hormone. [11] [12] [13] It is an estrogen and is used mainly in menopausal hormone therapy and to treat low sex hormone levels in women.
Although promoted as a way of customizing treatment, hormone therapy does not require customization; [38] the use of testing to determine the number of hormones administered could result in the dose being higher than the minimum recommended level to alleviate symptoms, [2] [8] or the administration of unnecessary hormones to asymptomatic women ...
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