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Dysautonomia, autonomic failure, or autonomic dysfunction is a condition in which the autonomic nervous system (ANS) does not work properly. This may affect the functioning of the heart, bladder, intestines, sweat glands, pupils, and blood vessels. Dysautonomia has many causes, not all of which may be classified as neuropathic. [5]
A tilt table test (TTT), occasionally called upright tilt testing (UTT), is a medical procedure often used to diagnose dysautonomia or syncope. Patients with symptoms of dizziness or lightheadedness, with or without a loss of consciousness ( fainting ), suspected to be associated with a drop in blood pressure or positional tachycardia are good ...
[12] [13] Further research identified multiple causes for these syndromic findings, now grouped as primary autonomic disorders (also called primary dysautonomia), including Pure Autonomic Failure, Multiple System Atrophy, and Parkinson's. The primary differentiating characteristic of Pure autonomic failure is decreased circulation and synthesis ...
Current tests for OI (tilt table test, NASA Lean Test, [13] adapted Autonomic Profile (aAP), [14] autonomic assessment, and vascular integrity) can also specify and simplify treatment. [9] Patients with dysautonomia symptoms can be referred to a cardiologist, neurologist, or even a gastroenterologist for treatment and management. [15] [16]
Orthostatic hypotension and significant gastrointestinal symptoms are also hallmarks of paraneoplastic dysautonomia. Paraneoplastic dysautonomia has been linked to thymoma, small-cell lung carcinoma, and, less frequently, breast cancer or lymphoma. At the time of the development of autonomic symptoms, the underlying malignancy is usually unknown.
Primary autonomic failure (also called primary dysautonomia) refers to a category of dysautonomias — conditions in which the autonomic nervous system does not function properly. In primary dysautonomias, the autonomic dysfunction occurs as a primary condition (as opposed to resulting from another disease). [ 1 ]
Paroxysmal sympathetic hyperactivity (PSH) is a syndrome that causes episodes of increased activity of the sympathetic nervous system.Hyperactivity of the sympathetic nervous system can manifest as increased heart rate, increased respiration, increased blood pressure, diaphoresis, and hyperthermia. [1]
This is a form of dysautonomia distinct from familial dysautonomia because of its lack of familial dysautonomic symptoms such as loss of sense of pain and smell. L-threo-DOPS has been described as being "very effective for restoring noradrenergic tone and correcting postural hypotension, response to treatment is variable and the long-term and ...