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The somatic mutation theory of ageing states that accumulation of mutations in somatic cells is the primary cause of aging. A comparison of somatic mutation rate across several mammal species found that the total number of accumulated mutations at the end of lifespan was roughly equal across a broad range of lifespans. [ 16 ]
Aging theories based on group selection; Antagonistic pleiotropy hypothesis; C. Cross-linking theory of aging; D. Disposable Soma Theory; ... Immune system theory of ...
The immunological theory of aging suggests that the immune system weakens as an organism ages. This makes the organism unable to fight infections and less able to destroy old and neoplastic cells. This leads to aging and will eventually lead to death. This theory of aging was developed by Roy Walford in 1969.
When your immune system tires out, disease risk goes up. But there are ways to keep your immunity young and strong. Chronic Stress May Speed Up Immune System Aging, Study Suggests
Stress hormones play a complex role in fighting diseases and infections, as they can have both positive and negative effects on the immune system. On one hand, stress hormones can enhance the immune response by stimulating the production of cytokines, which are molecules that regulate inflammation and immunity.
Biomedical theories hold that one can age successfully by caring for physical health and minimizing loss in function, whereas psychosocial theories posit that capitalizing upon social and cognitive resources, such as a positive attitude or social support from neighbors, family, and friends, is key to aging successfully. [7]
Strength of natural selection plot as a function of age. The antagonistic pleiotropy hypothesis (APT) is a theory in evolutionary biology that suggests certain genes may confer beneficial effects early in an organism's life, enhancing reproductive success, while also causing detrimental effects later in life, contributing to the aging process.
Aging is characterized by a progressive loss of physiological integrity, leading to impaired function and increased vulnerability to death. The hallmarks of aging are the types of biochemical changes that occur in all organisms that experience biological aging and lead to a progressive loss of physiological integrity, impaired function and, eventually, death.