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Tamoxifen is a pure antiestrogenic trans-isomer and has differential actions at estrogen target tissues throughout the body. Tamoxifen is selectively antiestrogenic in the breast but estrogen-like in bones and endometrial cancer. [24] Tamoxifen undergo phase I metabolism in the liver by microsomal cytochrome P450 (CYP) enzymes.
Tamoxifen is typically taken daily by mouth for five years for breast cancer. [14] Serious side effects include a small increased risk of uterine cancer, stroke, vision problems, and pulmonary embolism. [14] Common side effects include irregular periods, weight loss, and hot flashes. [14]
Anastrozole is used in the treatment and prevention of breast cancer in women. [7] The Arimidex, Tamoxifen, Alone or in Combination (ATAC) trial was of localized breast cancer and women received either anastrozole, the selective estrogen receptor modulator tamoxifen, or both for five years, followed by five years of follow-up. [13]
Regular physical activity can help accelerate weight loss, improve metabolism and enhance the benefits of weight loss pills. Aim for 150 minutes per week (or about a half-hour five days a week).
Scientists have found that the hormone therapy - called anastrozole - can p revent women from developing breast cancer and that the protective effect lasts for years after the treatment has ended.
1.25–2.5 mg 3x/day Ethinylestradiol: 0.15–3 mg/day Ethinylestradiol sulfonate: 1–2 mg 1x/week Diethylstilbestrol: 1–3 mg/day Dienestrol: 5 mg/day Hexestrol: 5 mg/day Fosfestrol: 100–480 mg 1–3x/day Chlorotrianisene: 12–48 mg/day Quadrosilan: 900 mg/day Estramustine phosphate: 140–1400 mg/day Transdermal patch: Estradiol: 2–6x ...
Surging demand has outpaced supply for Novo's Ozempic, Eli Lilly's Mounjaro and other GLP-1 drugs that promote weight loss, fueling a growing global market for counterfeit versions. The FDA said ...
Antiestrogens (or so-called "estrogen blockers") like aromatase inhibitors (AIs) (e.g., anastrozole) or selective estrogen receptor modulators (SERMs) (e.g., tamoxifen) can be used to reduce the effects of high levels of endogenous estrogen (e.g., breast development, feminine fat distribution) in transgender men.
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