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Hyperthermia is generally diagnosed by the combination of unexpectedly high body temperature and a history that supports hyperthermia instead of a fever. [2] Most commonly this means that the elevated temperature has occurred in a hot, humid environment (heat stroke) or in someone taking a drug for which hyperthermia is a known side effect ...
The resting human body generates about two-thirds of its heat through metabolism in internal organs in the thorax and abdomen, as well as in the brain. The brain generates about 16% of the total heat produced by the body. [8] Heat loss is a major threat to smaller creatures, as they have a larger ratio of surface area to volume.
Simplified control circuit of human thermoregulation. [8]The core temperature of a human is regulated and stabilized primarily by the hypothalamus, a region of the brain linking the endocrine system to the nervous system, [9] and more specifically by the anterior hypothalamic nucleus and the adjacent preoptic area regions of the hypothalamus.
Hyperthermia can set in when the core body temperature rises above 37.5–38.3 °C (99.5–100.9 °F). [3] [4] Humans have adapted to living in climates where hypothermia and hyperthermia were common primarily through culture and technology, such as the use of clothing and shelter. [5]
Thermoregulation is the ability of an organism to keep its body temperature within certain boundaries, even when the surrounding temperature is very different. A thermoconforming organism, by contrast, simply adopts the surrounding temperature as its own body temperature, thus avoiding the need for internal thermoregulation.
Function: An enzyme that is produced by animals that forms part of the innate immune system and is abundant in the secretions of saliva, human milk, tears, and mucus. It functions as an antimicrobial agent by splitting the peptidoglycan component of bacterial cell walls, which then leads to cell death.
Hyperthermia therapy (or hyperthermia, or thermotherapy) is a type of medical treatment in which body tissue is exposed to temperatures above body temperature, in the region of 40–45 °C (104–113 °F). Hyperthermia is usually applied as an adjuvant to radiotherapy or chemotherapy, to which it works as a sensitizer, in an effort to treat cancer.
Hyperthermia is an elevation of body temperature over the temperature set point, due to either too much heat production or not enough heat loss. [1] [7] Hyperthermia is thus not considered fever. [7]: 103 [40] Hyperthermia should not be confused with hyperpyrexia (which is a very high fever). [7]: 102