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It encodes expected outcomes, both positive and negative, and signals when the expected outcomes do not occur. The mPFC, mediated by the amygdala, is also involved in the extinction and modulation of conditioned responses, including emotional ones, and the augmentation of emotional states.
Cortical white matter increases from childhood (~9 years) to adolescence (~14 years), most notably in the frontal and parietal cortices. [8] Cortical grey matter development peaks at ~12 years of age in the frontal and parietal cortices, and 14–16 years in the temporal lobes (with the superior temporal cortex being last to mature), peaking at about roughly the same age in both sexes ...
There also appears to be a greater increase in neural activity in the left amygdala corresponding to an increasingly fearful stimulus. [n 10] [14] Recordings from single-unit electrodes in monkeys have shown similar activation in the left amygdala. [n 13] A man with confined damage in the right amygdala could not produce a startle response.
[1] Its various components support a variety of functions including emotion, behavior, long-term memory, and olfaction. [2] The limbic system is involved in lower order emotional processing of input from sensory systems and consists of the amygdala, mammillary bodies, stria medullaris, central gray and dorsal and ventral nuclei of Gudden. [3]
Each hemisphere is conventionally divided into four main lobes; the frontal lobe, parietal lobe, temporal lobe, and occipital lobe, named according to the skull bones that overlie them. [8] Each lobe is associated with one or two specialised functions though there is some functional overlap between them. [19]
The ventromedial prefrontal cortex (vmPFC) is a part of the prefrontal cortex in the mammalian brain.The ventral medial prefrontal is located in the frontal lobe at the bottom of the cerebral hemispheres and is implicated in the processing of risk and fear, as it is critical in the regulation of amygdala activity in humans. [2]
The uncinate fasciculus is a hook-shaped bundle of axons that links anterior portions of the temporal lobe with the inferior frontal gyrus and the lower surfaces of the frontal lobe. It arises in the anterior temporal lobe and amygdala , in the temporal lobe curving in an upward pathway behind the external capsule inward of the insular cortex ...
Patients with frontal lobe damage, such as Phineas Gage, provided the first evidence that the frontal lobes were associated with decision-making. Frontal lobe damage, particularly to the vmPFC, results in impaired abilities to organize and plan behavior and learn from previous mistakes, without affecting intellect in terms of working memory ...