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Actinobacillus pleuropneumoniae is a nonmotile, Gram-negative, encapsulated coccobacillus bacterium found in the family Pasteurellaceae. [4] [5] It exhibits β-hemolysis activity, [6] thus explaining its growth on chocolate or blood agar, but must be supplemented with NAD ('V factor') to facilitate growth for one of its biological variants (biovar 1). [3]
Actinobacillus is a genus of Gram-negative, nonmotile and non-spore-forming, oval to rod-shaped bacteria occurring as parasites or pathogens in mammals, birds, and reptiles. [1] It is a member of the family Pasteurellaceae . [ 2 ]
One proposed clade includes Aggregatibacter, Pasteurella, Actinobacillus succinogenes, Haemophilus influenzae, Haemophilus somnus, and Mannheimia succiniciproducens, while the other includes Actinobacillus minor, Actinobacillus pleuropneumoniae, Haemophilus ducreyi, Haemophilus parasuis, and Mannheimia haemolytica.
Clade II, encompassing Actinobacillus pleuropneumoniae, Actinobacillus minor, Haemophilus ducreyi, Mannheimia haemolytica and Haemophilus parasuis, was supported by 9 CSIs. Based on these results, it was proposed that Pasteurellales be divided from its current one family into two different ones.
Actinobacillus pleuropneumoniae has a glycosyltransferase homologous to HMW1C that can N-glycosylate the Haemophilus influenzae HMW1A protein. [13] The native substrates are autotransporter adhesins in Actinobacillus pleuropneumoniae [33] such as AtaC [34] and other pasteurellaceae. [35]
In the European Union, tildipirosin is indicated for the treatment and metaphylaxis of swine respiratory disease associated with Actinobacillus pleuropneumoniae, P. multocida, Bordetella bronchiseptica, and Glaesserella parasuis sensitive to tildipirosin; [3] and for the treatment and prevention of bovine respiratory disease associated with M ...
Actinobacillus suis is a beta-haemolytic, Gram-negative bacterium of the family Pasteurellaceae. The bacterium has many strains and is the pathogen responsible for actinobacillosis in pigs of all ages. It can also infect wild birds, domestic ruminants, dogs, cats, and horses.
HACEK is an abbreviation of the initials of the genera of this group of bacteria: Haemophilus, Aggregatibacter (previously Actinobacillus), Cardiobacterium, Eikenella, Kingella. [1] The HACEK organisms are a normal part of the human microbiota, living in the oral-pharyngeal region. [2]