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Soluble guanylate cyclase (sGC) stimulators are a class of drugs developed to treat heart failure, pulmonary hypertension, and other diseases. The first-in-class medication was riociguat , approved in 2013 for pulmonary hypertension.
PSA was launched in July 1991 by David Hall, owner of the coin grading company Professional Coin Grading Service (PCGS), to serve collectors as a third-party card grader. [1] At the outset, the business faced difficulties owing to a limited demand from collectors who sought card grading services. [ 2 ]
Soluble guanylyl cyclase (sGC) is one of the gasoreceptors for nitric oxide, NO. It is soluble, i.e. completely intracellular. It is soluble, i.e. completely intracellular. Most notably, this enzyme is involved in vasodilation .
The first nitric oxide (NO) independent, haem-dependent sGC stimulator, YC-1, a synthetic benzylindazole derivative, was described in 1978. [14] The characterisation 20 years later demonstrated that as well as increasing sGC activity, YC-1 acted in synergy with NO to stimulate sGC. However, YC-1 was a relatively weak vasodilator and had side ...
Serial numbered #3/10 PSA GM-MT 10 January 30, 2021 Goldin Auctions Set record for a non-autographed Luka Doncic Rookie Card. 29 $929,004 $700,000 Eddie Plank: 1909–11 T206: c. 110 [33] [9] [10] PSA 7 2012: Private sale Like the T206 Honus Wagner, the reason for the scarcity of T206 Plank cards is unknown. [34] [35] [36] 30 $910,268 $717,000 ...
Development of the vehicle by PSA Group took seven years due to its radical concept, and was led by project manager Aurélie Bresson. [10] [11] The vehicle was codenamed as the P54 during development. [11] The design was inspired from an internal concept car that Peugeot had worked on, which was known as the "2015 Advanced Design manifesto". [12]
The PSA Certified program seeks to address and reduce fragmentation in the IoT product manufacturing and development sectors. It supports the creation of system-on-chips (SoCs) that incorporate a PSA Root of Trust (PSA-RoT), a security component accessible to software platforms and original equipment manufacturers (OEMs).
The Citroën C3 Aircross is a nameplate designated to several vehicles produced under the Citroën marque, by the French automaker PSA Group, and later Stellantis.. The first vehicle using the nameplate was the Brazilian version of the C3 Picasso MPV, decorated to mimic an SUV exterior design, which was produced between 2010 and 2020.