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  2. Gene therapy - Wikipedia

    en.wikipedia.org/wiki/Gene_therapy

    This is one of the first studies of a CRISPR-based in vivo human gene editing therapy, where the editing takes place inside the human body. [266] The first injection of the CRISPR-Cas System was confirmed in March 2020. [267] Exagamglogene autotemcel, a CRISPR-based human gene editing therapy, was used for sickle cell and thalassemia in ...

  3. Genetic engineering techniques - Wikipedia

    en.wikipedia.org/wiki/Genetic_engineering_techniques

    Genetic engineering techniques allow the modification of animal and plant genomes.Techniques have been devised to insert, delete, and modify DNA at multiple levels, ranging from a specific base pair in a specific gene to entire genes.

  4. Human genetic enhancement - Wikipedia

    en.wikipedia.org/wiki/Human_genetic_enhancement

    With the discovery of various types of immune-related disorders, there is a need for diversification in prevention and treatment. Developments in the field of gene therapy are being studied to be included in the scope of this treatment, but of course more research is needed to increase the positive results and minimize the negative effects of gene therapy applications. [27]

  5. List of gene therapies - Wikipedia

    en.wikipedia.org/wiki/List_of_gene_therapies

    "Gene Therapy Arrives". Scientific American This page was last edited on 10 November 2024, at 06:28 (UTC). Text is available under the Creative Commons Attribution ...

  6. Gene delivery - Wikipedia

    en.wikipedia.org/wiki/Gene_delivery

    Gene delivery is a necessary step in gene therapy for the introduction or silencing of a gene to promote a therapeutic outcome in patients and also has applications in the genetic modification of crops. There are many different methods of gene delivery for various types of cells and tissues.

  7. Molecular cloning - Wikipedia

    en.wikipedia.org/wiki/Molecular_cloning

    The first is alteration of germ cells, that is, sperm or eggs, which results in a permanent genetic change for the whole organism and subsequent generations. This "germ line gene therapy" is considered by many to be unethical in human beings. [22] The second type of gene therapy, "somatic cell gene therapy", is analogous to an organ transplant.

  8. Gene targeting - Wikipedia

    en.wikipedia.org/wiki/Gene_targeting

    A chimeric mouse gene targeted for the agouti coat color gene, with its offspring. Gene targeting is a biotechnological tool used to change the DNA sequence of an organism (hence it is a form of Genome Editing). It is based on the natural DNA-repair mechanism of Homology Directed Repair (HDR), including Homologous Recombination. Gene targeting ...

  9. Vectors in gene therapy - Wikipedia

    en.wikipedia.org/wiki/Vectors_in_gene_therapy

    How vectors work to transfer genetic material. Gene therapy utilizes the delivery of DNA into cells, which can be accomplished by several methods, summarized below. The two major classes of methods are those that use recombinant viruses (sometimes called biological nanoparticles or viral vectors) and those that use naked DNA or DNA complexes (non-viral methods).

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