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A film coating is a thin polymer-based coat that is typically sprayed onto solid pharmaceutical dosage forms, such as tablets, capsules, pellets or granules.Film coating can impact both its appearance and its pharmacokinetics making it an essential process in making the final drug product.
Pharmaceutical manufacturing is the process of industrial-scale synthesis of pharmaceutical drugs as part of the pharmaceutical industry. The process of drug manufacturing can be broken down into a series of unit operations , such as milling , granulation , coating , tablet pressing , and others.
Pharmaceutical engineering is a branch of engineering focused on discovering, formulating, and manufacturing medication, analytical and quality control processes, and on designing, building, and improving manufacturing sites that produce drugs.
ASME BPE (American Society of Mechanical Engineers: Bioprocessing Equipment) is an international Standard developed as an aid for the design and construction of equipment intended for use in the manufacturing of biopharmaceuticals. The standard is approved as an American National Standard by the ASME Board of Pressure Technologies.
The bilayers and wash steps can be performed in many different ways including dip coating, spin-coating, spray-coating, flow based techniques and electro-magnetic techniques. [1] The preparation method distinctly impacts the properties of the resultant films, allowing various applications to be realized. [ 1 ]
BS 4994:1987 – Specification for design and construction of vessels and tanks in reinforced plastics. British Standards. 1987-06-30. ISBN 0-580-15075-5. "Pressure Vessel Design Case Study". ESR Technology. Archived from the original on 2007-05-12. — a case study of the design process of a cylindrical vessel, using the BS 4994 methodology
There are two types of coating machines used in the pharmaceutical industry: coating pans and automatic coaters. [14] Coating pans are used mostly to sugar coat pellets. Automatic coaters are used for all kinds of coatings; they can be equipped with a remote control panel, a dehumidifier, and dust collectors.
Various thin film characterization techniques can be used to measure the physical properties of PVD coatings, such as: Calo tester: coating thickness test; Nanoindentation: hardness test for thin-film coatings; Pin-on-disc tester: wear and friction coefficient test; Scratch tester: coating adhesion test