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Urolithin A is a metabolite compound resulting from the transformation of ellagitannins by the gut bacteria. [1] It belongs to the class of organic compounds known as benzo- coumarins or dibenzo-α- pyrones .
Chemical structure of urolithin A.. Urolithins are microflora metabolites of dietary ellagic acid derivatives, such as ellagitannins. [1] They are produced in the gut, and found in the urine in the form of urolithin B glucuronide after absorption of ellagitannins-containing foods, such as pomegranate. [2]
Toxicity results from ingesting too much preformed vitamin A from foods (such as liver), supplements, or prescription medications and can be prevented by ingesting no more than the recommended daily amount. Diagnosis can be difficult, as serum retinol is not sensitive to toxic levels of vitamin A, but there are effective tests available.
No underlying causes Gastroenterologic Acute fatty liver of pregnancy , Acute liver failure , Cirrhosis , Diabetic gastroparesis , Diarrhea , Dumping syndrome , Functioning pancreatic endocrine tumor , Gastric dumping syndrome , Hepatic congestion , Hepatic failure , Idiopathic postprandial syndrome , Insulinoma , Liver cancer , Malabsorption ...
In about 10% of cases the blood sugar is not significantly elevated ("euglycemic diabetic ketoacidosis"). [3] A pH measurement is performed to detect acidosis. Blood from a vein is adequate, as there is little difference between the arterial and the venous pH; arterial samples are only required if there are concerns about oxygen levels. [6]
Sustained higher levels of blood sugar cause damage to the blood vessels and to the organs they supply, leading to the complications of diabetes. [48] Chronic hyperglycemia can be measured via the HbA1c test. The definition of acute hyperglycemia varies by study, with mmol/L levels from 8 to 15 (mg/dL levels from 144 to 270). [49]
It may also affect blood sugar levels and blood pressure. Pineapple enzyme Ananas comosus: Bromelain "Diarrhea, increased tendency for bleeding if used simultaneously with anticoagulants and inhibitors of thrombocytic aggregation due to modulation of the arachidonate cascade" [3] Psyllium seed Plantago spp Coumarin derivates Retards absorption ...
The levels of the toxin decrease over time though from approximately 1000 ppm to around 0.1 ppm in the mature fruit. [ 4 ] Relatives of Ackee, including lychee , longan , and rambutan , can contain enough α-(methylenecyclopropyl)glycine, a homologue of hypoglycin A, in their fruit to cause hypoglycemic encephalopathy in undernourished children ...
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