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No metabolic toxification reactions are known for soman. Soman can be hydrolyzed by a so-called A-esterase, more specific a diisopropylfluorophosphatase. This esterase, also called somanase, reacts with the anhydride bond between phosphorus and fluorine and accounts for the hydrolysis of the fluoride.
OPAA’s susbstrate-specificity to organophosphorus-containing compounds, especially fluoride-containing G-type nerve agents such as sarin, cyclosarin, tabun, and soman, [13] [14] have drawn the interest of the U.S. Army . That attention has resulted in the establishment of a biodegradation program in search of safe and effective means of ...
The reaction product of the most important nerve agents, including Soman, Sarin, Tabun and VX, with acetylcholinesterase were solved by the U.S. Army using X-ray crystallography in the 1990s. [ 10 ] [ 11 ] The reaction products have been confirmed subsequently using different sources of acetylcholinesterase and the closely related target enzyme ...
However, compared with other highly toxic nerve agents like soman or sarin, VX undergoes relatively slow "aging". Aging is a time-dependent side reaction (loss of an alkoxyl group) that occurs on nerve agents after phosphorylation and renders the nerve agent-acetylcholinesterase complex highly resistant to regeneration by any known antidote.
It's a colorless liquid that is extremely resistant to hydrolysis. [3] DCFP can be produced by reaction of cyclohexanol with phosphoryl dichloride fluoride. [2] [3 ...
The most important chemical reactions of phosphoryl halides is the hydrolysis of the bond between phosphorus and the fluorine atom. This P-F bond is easily broken by nucleophilic agents, such as water and hydroxide. At high pH, sarin decomposes rapidly to nontoxic phosphonic acid derivatives.
590 12038 Ensembl ENSG00000114200 ENSMUSG00000027792 UniProt P06276 Q03311 RefSeq (mRNA) NM_000055 NM_009738 RefSeq (protein) NP_000046 NP_033868 Location (UCSC) Chr 3: 165.77 – 165.84 Mb Chr 3: 73.54 – 73.62 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Butyrylcholinesterase (HGNC symbol BCHE ; EC 3.1.1.8), also known as BChE, BuChE, BuChase, pseudocholinesterase, or plasma ...
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