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4128 17161 Ensembl ENSG00000189221 ENSMUSG00000025037 UniProt P21397 Q64133 RefSeq (mRNA) NM_001270458 NM_000240 NM_173740 RefSeq (protein) NP_000231 NP_001257387 NP_776101 Location (UCSC) Chr X: 43.65 – 43.75 Mb Chr X: 16.49 – 16.55 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse MAOA gene is located on the short (p) arm of the X chromosome at position 11.3. Monoamine oxidase A ...
Brunner syndrome is a rare genetic disorder associated with a mutation in the MAOA gene.It is characterized by lower than average IQ (typically about 85), problematic impulsive behavior (such as pyromania, hypersexuality and violence), sleep disorders and mood swings.
Monoamine oxidases (MAO) (EC 1.4.3.4) are a family of enzymes that catalyze the oxidation of monoamines, employing oxygen to clip off their amine group.
MAO-A inhibition reduces the breakdown of primarily serotonin, norepinephrine, and dopamine; selective inhibition of MAO-A allows for tyramine to be metabolised via MAO-B. [43] Agents that act on serotonin, if taken with another serotonin-enhancing agent, may result in a potentially fatal interaction called serotonin syndrome; if taken with ...
Rasagiline, sold under the brand name Azilect among others, is a medication which is used in the treatment of Parkinson's disease. [2] [6] It is used as a monotherapy to treat symptoms in early Parkinson's disease or as an adjunct therapy in more advanced cases. [7]
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Due to longstanding pushback and controversial health studies surrounding the ingredient, many processed food manufacturers have already shifted away from using Red Dye No. 3, opting instead for ...
The non-selective MAO-A and MAO-B inhibitor tranylcypromine has been frequently used to potentiate the effects of 5-MT in animal studies. [11] [29] [31] [15] [16] 5-MT is orally inactive in humans presumably due to rapid metabolism by MAO-A. [1] [2] Metabolites of 5-MT include 5-methoxyindole-3-acetic acid (5-MIAA) and 5-methoxytryptophol.