Search results
Results from the WOW.Com Content Network
Retinol-binding protein 4 has been a drug target for eye diseases as RBP4 is the sole carrier for retinol, which is an essential nutrient for the visual cycle. Animal studies using RBP4-antagonists showed that lowering RBP4 can lead to reduction in the accumulation of lipofuscin that leads to vision loss in eye diseases like Stargardt's disease ...
Retinol plays a crucial role in the growth and differentiation of various body tissues, and it has been previously characterized that embryos are extremely sensitive to alterations in retinol concentration that can lead to spontaneous abortion and malformations occurring during development.
Anophthalmia (Greek: ἀνόφθαλμος, "without eye") is the medical term for the absence of one or both eyes. Both the globe and the ocular tissue are missing from the orbit. [ 1 ] The absence of the eye will cause a small bony orbit, a constricted mucosal socket , short eyelids , reduced palpebral fissure and malar prominence . [ 2 ]
5928 19646 Ensembl ENSG00000162521 ENSMUSG00000057236 UniProt Q09028 Q60972 RefSeq (mRNA) NM_005610 NM_001135255 NM_001135256 NM_009030 RefSeq (protein) NP_001128727 NP_001128728 NP_005601 NP_033056 Location (UCSC) Chr 1: 32.65 – 32.69 Mb Chr 4: 129.2 – 129.23 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Histone-binding protein RBBP4 (also known as RbAp48, or NURF55) is a ...
Retinoic acid is actively transported into the cell nucleus by CRABp2 where it regulates thousands of genes by binding directly to gene targets via retinoic acid receptors. [ 6 ] In addition to retinol, retinal and retinoic acid, there are plant-, fungi- or bacteria-sourced carotenoids which can be metabolized to retinol, and are thus vitamin A ...
Microphthalmia (Greek: μικρός, mikros, 'small', ὀφθαλμός, ophthalmos, 'eye'), also referred as microphthalmos, is a developmental disorder of the eye in which one (unilateral microphthalmia) or both (bilateral microphthalmia) eyes are abnormally small and have anatomic malformations.
Retinoblastoma (Rb) is a rare form of cancer that rapidly develops from the immature cells of a retina, [2] the light-detecting tissue of the eye. [3] It is the most common primary malignant intraocular cancer in children, and 80% of retinoblastoma cases are first detected in those under 3 years old.
5433 69241 Ensembl ENSG00000144231 ENSMUSG00000024258 UniProt O15514 Q9D7M8 RefSeq (mRNA) NM_004805 NM_027002 NM_001357480 RefSeq (protein) NP_004796 NP_081278 NP_001344409 Location (UCSC) Chr 2: 127.84 – 127.86 Mb Chr 18: 31.92 – 31.93 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse DNA-directed RNA polymerase II subunit RPB4 is an enzyme that in humans is encoded by the POLR2D ...