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Subacute combined degeneration of spinal cord, also known as myelosis funiculus, or funicular myelosis, [1] also Lichtheim's disease, [2] [3] and Putnam-Dana syndrome, [4] refers to degeneration of the posterior and lateral columns of the spinal cord as a result of vitamin B 12 deficiency (most common).
[1] [2] Other uses include treatment for cyanide poisoning, Leber's optic atrophy, and toxic amblyopia. [3] [4] It is given by injection into a muscle or vein, [2] by pill or sublingually. Side effects are generally few. [2] They may include diarrhea, feeling sick, hot flushes, itchiness, low blood potassium, allergic reactions, and high blood ...
Treatment using oral drugs is an easier option in management but the bioavailability of B12 is low. This is due to low absorption in the intestine, and breakdown by enzyme activity. Research continues to focus on the use of permeation enhancers or permeation absorbers in combination with the treatment.
Derrick Lonsdale (April 22, 1924 – May 2, 2024) was a British-born American pediatrician and researcher into the benefits of certain nutrients in preventing disease and psychotic behavior.
Cleveland Clinic Marymount Hospital is a 322-bed acute-care facility located in Garfield Heights, Ohio. The hospital primarily serves southern and southeastern Cuyahoga County. Marymount provides cancer care, cardiology, diabetes, emergency, orthopaedics, outpatient rehabilitation, stroke care, vascular surgery, and women's health.
Cyanocobalamin is a form of vitamin B 12 used to treat and prevent vitamin B 12 deficiency except in the presence of cyanide toxicity. [7] [8] [2] The deficiency may occur in pernicious anemia, following surgical removal of the stomach, with fish tapeworm, or due to bowel cancer.
Cleveland Medical Center and Case School of Medicine together form the largest biomedical research center in Ohio. [8] In biomedical research, Case Medical Center ranks among top 15 centers in the United States with approximately $75 million in annual extramural research funding and a further $20 million in various clinical trials. [8]
The Schilling test has multiple stages. [3] As noted below, it can be done at any time after vitamin B 12 supplementation and body store replacement, and some clinicians recommend that in severe deficiency cases, at least several weeks of vitamin repletion be done before the test (more than one B 12 shot, and also oral folic acid), in order to ensure that impaired absorption of B 12 (with or ...