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Hydroxycarbamide has been used primarily for the treatment of myeloproliferative diseases, which has an inherent risk of transforming to acute myeloid leukemia. There has been a longstanding concern that hydroxycarbamide itself carries a leukemia risk, but large studies have shown that the risk is either absent or very small.
Each drug is listed once (at present), though it might fall in more than one subsection. A full alphabetical listing is included after the categorical listing. The agents in this list are often combined into chemotherapy agent for polychemotherapy (combination chemotherapy).
Hydroxycarbamide: PO: Inhibits DNA synthesis by inhibiting the enzyme ribonucleotide reductase. Chronic myeloid leukaemia, essential thrombocytosis, polycythaemia vera, myelofibrosis, acute myeloid leukaemia and sickle cell anaemia: Myelosuppression, skin cancer (rare), oedema (rare), hallucinations (rare), seizures (rare) and pulmonary ...
"DNA synthesis in multiple myeloma cells following cell cycle-nonspecific chemotherapy". Cancer Res. 34 (11): 2911– 4. PMID 4424360. Ozawa S, Sugiyama Y, Mitsuhashi Y, Kobayashi T, Inaba M (1988). "Cell killing action of cell cycle phase-non-specific antitumor agents is dependent on concentration--time product". Cancer Chemother. Pharmacol.
A chemotherapy regimen is a regimen for chemotherapy, defining the drugs to be used, their dosage, the frequency and duration of treatments, and other considerations. In modern oncology, many regimens combine several chemotherapy drugs in combination chemotherapy. The majority of drugs used in cancer chemotherapy are cytostatic, many via ...
Pardue, 31, was eventually diagnosed with late-stage 3 cervical cancer — and underwent chemotherapy and other treatment before she would have been due for her next pap smear.
The group also said it had $500,000 worth of antibiotics, antimalarial drugs and other essential medicines currently stuck at the Port of Sudan because of the Trump administration’s stop-work order.
The drug methotrexate (bottom) is an antimetabolite that interferes with the metabolism of folic acid (top). An antimetabolite is a chemical that inhibits the use of a metabolite, which is another chemical that is part of normal metabolism. [1]