Search results
Results from the WOW.Com Content Network
Free-radical theory of aging; G. ... Immune system theory of aging; Inflammation theory of aging; M. Maintenance theories of aging; Mitohormesis; N. Network theory of ...
Telomere dysfunction during cellular aging (a state in which cells do not divide but are metabolically active) affects the health of the body. [2] Preventing telomere shortening without clearing old cells may lead to the accumulation of these cells in the body and contribute to age-related diseases and tissue dysfunction.
Free-radical theory of aging; G. ... Immune system theory of aging; Inflammation theory of aging; M. Maintenance theories of aging; Mitohormesis; N. Network theory of ...
Not only does p16 play an important role in aging, but also in auto-immune diseases like rheumatoid arthritis that progressively lead to mobility impairment in advanced disease. [ 42 ] In the nervous system, senescence has been described in astrocytes and microglia, but is less understood in neurons. [ 22 ]
The free-radical theory of aging proposes that this damage cumulatively degrades the biological function of cells and impacts the process of aging. [18] The idea that free radicals are toxic agents was first proposed by Rebeca Gerschman and colleagues in 1945, [19] but came to prominence in 1956, when Denham Harman proposed the free-radical ...
The metabolic stability theory of aging suggests it is the cells ability to maintain stable concentration of ROS which is the primary determinant of lifespan. [37] This theory criticizes the free radical theory because it ignores that ROS are specific signalling molecules which are necessary for maintaining normal cell functions. [37]
The mitochondrial theory of ageing has two varieties: free radical and non-free radical. The first is one of the variants of the free radical theory of ageing. It was formulated by J. Miquel and colleagues in 1980 [1] and was developed in the works of Linnane and coworkers (1989). [2] The second was proposed by A. N. Lobachev in 1978. [3]
Aging is characterized by a progressive loss of physiological integrity, leading to impaired function and increased vulnerability to death. The hallmarks of aging are the types of biochemical changes that occur in all organisms that experience biological aging and lead to a progressive loss of physiological integrity, impaired function and, eventually, death.