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And the 5% strength seems to be more effective than minoxidil 2%. (Learn more about How Long Does Minoxidil Take to Work?.) What the Research Says. A 2002 study compared 5% and 2% minoxidil ...
Also, women who are pregnant or trying to become pregnant generally cannot use the medication as it is a teratogen, and can cause ambiguous genitalia in newborn children. [ 34 ] There is tentative evidence for flutamide in women; however, it is associated with relatively high rates of liver problems and strong recommendations have been made ...
The fact that Rogaine is a name brand doesn’t mean that it’s any more effective at preventing hair loss or safer to use than generic minoxidil — both contain exactly the same active ...
A 48-week clinical trial compared 5% and 2% minoxidil in almost 400 men with male pattern baldness. The 5% minoxidil solution resulted in 45 percent more hair regrowth than the 2% topical minoxidil.
In 2017, a study of pharmacy prices in four states for 41 over-the-counter minoxidil products which were "gender-specified" found that the mean price for minoxidil solutions was the same for women and men even though the women's formulations were 2% and the men's were 5%, while the mean price for minoxidil foams, which were all 5%, was 40% ...
The SULT1A1 enzyme is expressed in outer roots sheath of hair follicles. Minoxidil, the only US FDA approved topical drug for re-growing hair in male and female pattern hair loss (androgenetic alopecia patients) is a pro-drug. Minoxidil is converted to its active form (minoxidil sulfate) by the hair sulfotransferase enzyme (SULT1A1). [6]
Minoxidil (brand name Rogaine®) is a non-prescription topical medication that promotes hair growth and regrowth by restarting the growth phase in dormant hair follicles.
[1] [3] Its mechanism of action in terms of hair growth is still unknown, although multiple potential mechanisms have been implicated. [1] Minoxidil sulfate is a sulfate ester of minoxidil, not a sulfate salt of the compound. [3] However, minoxidil sulfate forms an inner salt, which makes it more hydrophobic than minoxidil. [3]