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Acrocephalosyndactyly presents in numerous different subtypes, however, considerable overlap in symptoms occurs. Generally, all forms of acrocephalosyndactyly are characterized by atypical craniofacial, hand, and foot characteristics, such as premature closure of the fibrous joints in between certain bones of the skull, [16] [17] fusion of certain fingers or toes, [16] [18] and/or more than ...
Polysyndactyly may be classified by the level of duplication. The extra digit may be small and comprise only soft tissue, [7] but usually includes at least one bone, most commonly the distal and middle phalanges. [4] [8] Partial or complete duplication of the proximal phalanx, metacarpal or metatarsal can also occur. [4] [7]
The scientific name for the condition is syndactyly, although this term covers both webbed fingers and webbed toes. Syndactyly occurs when apoptosis or programmed cell death during gestation is absent or incomplete. Webbed toes occur most commonly in the following circumstances: [1] Syndactyly or familial syndactyly; Down syndrome
Webbing between the second and third finger and between the second and third toes [2] Short fingers and toes (brachydactyly) [4] Broad thumb and/or a broad hallux (big toe) with a valgus deformity (outward angulation of the distal segment of a bone/joint) [6] Hands have a single palmar flexion crease [3]
Syndactyly can be simple or complex. [2] In simple syndactyly, adjacent fingers or toes are joined by soft tissue. In complex syndactyly, the bones of adjacent digits are fused. The kangaroo exhibits complex syndactyly. Syndactyly can be complete or incomplete. In complete syndactyly, the skin is joined all the way to the tip of the involved ...
The skin between the fingers and toes may be fused (cutaneous syndactyly). This disorder is also characterized by widely spaced eyes (ocular hypertelorism), an abnormally large head size (macrocephaly), and a high, prominent forehead. Rarely, affected individuals may have more serious medical problems including seizures and developmental delay. [1]
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Synpolydactyly type 1 (SPD1), also known as syndactyly type II, is a genetic limb disorder caused by inheritance of at least one rare allele of the HOXD13 gene. [7] In heterozygous cases, where individuals have one rare HOXD13 allele, common symptoms include fused third and fourth fingers, sometimes with an extra small finger within the webbing.