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In humans, GHK-Cu is proposed to promote wound healing, attraction of immune cells, antioxidant and anti-inflammatory effects, stimulation of collagen and glycosaminoglycan synthesis in skin fibroblasts and promotion of blood vessels growth. Recent studies revealed its ability to modulate expression of a large number of human genes, generally ...
51129 57875 Ensembl ENSG00000167772 ENSMUSG00000002289 UniProt Q9BY76 Q9Z1P8 RefSeq (mRNA) NM_001039667 NM_016109 NM_139314 NM_020581 RefSeq (protein) NP_001034756 NP_647475 NP_065606 Location (UCSC) Chr 19: 8.36 – 8.37 Mb Chr 17: 33.99 – 34 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Angiopoietin-like 4 is a protein that in humans is encoded by the ANGPTL4 gene ...
Diabetic foot ulcer is a breakdown of the skin and sometimes deeper tissues of the foot that leads to sore formation. It is thought to occur due to abnormal pressure or mechanical stress chronically applied to the foot, usually with concomitant predisposing conditions such as peripheral sensory neuropathy, peripheral motor neuropathy, autonomic neuropathy or peripheral arterial disease. [1]
Slow wound healing. Chronically high blood sugar levels in patients with advanced diabetes can lead to nerve and blood vessel damage. It could also cause diabetic retinopathy or peripheral neuropathy.
Timing is important to wound healing. Critically, the timing of wound re-epithelialization can decide the outcome of the healing. [11] If the epithelization of tissue over a denuded area is slow, a scar will form over many weeks, or months; [12] [13] If the epithelization of a wounded area is fast, the healing will result in regeneration.
A growth factor is a naturally occurring substance capable of stimulating cell proliferation, wound healing, and occasionally cellular differentiation. [1] Usually it is a secreted protein or a steroid hormone. Growth factors are important for regulating a variety of cellular processes. Growth factors typically act as signaling molecules ...
Ulcers on foot are common in a patient with severe diabetes due to the prolonged impairment of wound healing. [4] Pro-inflammatory (M1) macrophages are also frequently observed in obese individuals' subcutaneous tissues. This is related to the progression of diabetes with chronic adipose tissue inflammation. [4]
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related to: protein to promote wound healing in diabetic patients