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Clopidogrel, sold under the brand name Plavix among others, is an antiplatelet medication used to reduce the risk of heart disease and stroke in those at high risk. [10] It is also used together with aspirin in heart attacks and following the placement of a coronary artery stent ( dual antiplatelet therapy ). [ 10 ]
Fecal incontinence or constipation occurs when there is a problem with normal bowel functioning. This could be for a variety of reasons. The normal defecation pathway involves contractions of the colon which helps mix the contents, absorb water and propel the contents along. This results in feces moving along the colon to the rectum. [4]
As such, the relatively poor selectivity profile of cisapride versus other receptors (especially hERG [human ether-a-go-go K +] channels) contributes to its potential to cause cardiac arrhythmias. Prucalopride , a first in class benzofuran , is a selective, high affinity serotonin (5-HT 4 ) receptor agonist that stimulates colonic mass ...
Lubiprostone is a laxative used for the treatment of constipation, specifically: [9] Chronic idiopathic constipation (difficult or infrequent passage of stools that lasts for 3 months or longer and is not caused by diet, disease, or drugs).
For those who like to dive really deep into the science, GLP-1 (short for glucagon-like peptide-1) is a naturally occurring hormone that regulates insulin and promotes feelings of fullness.
Macrogol 4000, pharmaceutical quality. Macrogol 3350, often in combination with electrolytes, is used for short-term relief of constipation as well as for long-term use in constipation of various causes, including in multiple sclerosis and Parkinson's disease patients (an often-overlooked non-motor symptom) as well as constipation caused by pharmaceutical drugs such as opioids and ...
Chemically, naloxegol is a pegylated (polyethylene glycol-modified) derivative of α-naloxol.Specifically, the 6-α-hydroxyl group of α-naloxol is connected via an ether linkage to the free hydroxyl group of a monomethoxy-terminated n=7 oligomer of PEG, shown extending at the lower left of the molecule image at right.
Prucalopride is contraindicated where there is hypersensitivity to the active substance or to any of the excipients, renal impairment requiring dialysis, intestinal perforation or obstruction due to structural or functional disorder of the gut wall, obstructive ileus, severe inflammatory conditions of the intestinal tract, such as Crohn's disease, and ulcerative colitis and toxic megacolon ...