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The following list contains adverse effects by incidence of trimethoprim ... (low number of platelets in the blood) Infrequently (0.1–1.0% frequency) ...
The effects of trimethoprim causes a backlog of dihydrofolate (DHF) and this backlog can work against the inhibitory effect the drug has on tetrahydrofolate biosynthesis. This is where the sulfamethoxazole comes in; its role is in depleting the excess DHF by preventing it from being synthesised in the first place.
However, some blood pressure medications have a side effect of making you feel sleepy during the day, regardless of how many Zzzs you get at night. "Others, like beta blockers, can be taken at ...
Common side effects include nausea, changes in taste, and rash. [1] Rarely it may result in blood problems such as not enough platelets or white blood cells. [1] Trimethoprim may cause sun sensitivity. [1] There is evidence of potential harm during pregnancy in some animals but not humans. [3]
For most people, recommendations are to reduce blood pressure to less than or equal to somewhere between 140/90 mmHg and 160/100 mmHg. [2] In general, for people with elevated blood pressure, attempting to achieve lower levels of blood pressure than the recommended 140/90 mmHg will create more harm than benefits, [3] in particular for older people. [4]
[34] [35] Bitter oranges (such as the Seville oranges often used in marmalade) can interfere with drugs [38] including etoposide, a chemotherapy drug, some beta blocker drugs used to treat high blood pressure, and cyclosporine, taken by transplant patients to prevent rejection of their new organs. [12] Evidence on sweet oranges is more mixed. [11]
The angiotensin II receptor blockers have differing potencies in relation to blood pressure control, with statistically differing effects at the maximal doses. [12] When used in clinical practice, the particular agent used may vary based on the degree of response required. [citation needed] Some of these drugs have a uricosuric effect. [13] [14]
Sulfamethoxazole (SMZ or SMX) is an antibiotic.It is used for bacterial infections such as urinary tract infections, bronchitis, and prostatitis and is effective against both gram negative and positive bacteria such as Escherichia coli and Listeria monocytogenes.
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