Search results
Results from the WOW.Com Content Network
In general, biological aging clocks and biomarkers of aging are expected to find many uses in biological research since age is a fundamental characteristic of most organisms. Accurate measures of biological age (biological aging clocks) could be useful for testing the validity of various theories of biological aging,
The DNA damage theory of aging postulates that DNA damage is ubiquitous in the biological world and is the primary cause of ageing. [27] The theory is based on the idea that ageing occurs over time due to the damage of the DNA.
Genetic theories of aging propose that aging is programmed within each individual's genes. According to this theory, genes dictate cellular longevity. Programmed cell death, or apoptosis, is determined by a "biological clock" via genetic information in the nucleus of the cell. Genes responsible for apoptosis provide an explanation for cell ...
As women age, ovarian reserve -- which is defined as the quantity and the quality of the eggs remaining in the ovaries -- declines, and when all eggs are depleted, menopause starts and ...
Horvath and Raj proposed an epigenetic clock theory of aging [25] which views biological aging as an unintended consequence of both developmental programs and maintenance program, the molecular footprints of which give rise to DNA methylation age estimators. DNAm age is viewed as a proximal readout of a collection of innate ageing processes ...
The main mechanisms identified as potential biomarkers of aging are DNA methylation, loss of histones, and histone modification. The uses for biomarkers of aging are ubiquitous and identifying a physical parameter of biological aging would allow humans to determine our true age, mortality, and morbidity. [10]
The metabolic stability theory of aging suggests it is the cells ability to maintain stable concentration of ROS which is the primary determinant of lifespan. [37] This theory criticizes the free radical theory because it ignores that ROS are specific signalling molecules which are necessary for maintaining normal cell functions. [37]
For premium support please call: 800-290-4726 more ways to reach us