Search results
Results from the WOW.Com Content Network
The duration of action of a drug is the length of time that particular drug is effective. [5] Duration of action is a function of several parameters including plasma half-life, the time to equilibrate between plasma and target compartments, and the off rate of the drug from its biological target. [6]
The action of drugs on the human body (or any other organism's body) is called pharmacodynamics, and the body's response to drugs is called pharmacokinetics. The drugs that enter an individual tend to stimulate certain receptors, ion channels, act on enzymes or transport proteins. As a result, they cause the human body to react in a specific way.
Onset of action is the duration of time it takes for a drug's effects to come to prominence upon administration. With oral administration , it typically ranges anywhere from 20 minutes to over an hour, depending on the drug in question.
In pharmacology, the area under the plot of plasma concentration of a drug versus time after dosage (called “area under the curve” or AUC) gives insight into the extent of exposure to a drug and its clearance rate from the body. [2]
The Miller-Keane Encyclopedia & Dictionary of Medicine, Nursing, and Allied Health is written for use by students and health care providers including medics, nurses, and paramedics. The entries are alphabetical and compiled with multidisciplinary collaboration.
Molecular pharmacology – the discipline of studying drug actions at the molecular level; it is a branch of pharmacology in general. Pharmacogenomics – the study of the human genome in order to understand the ways in which genetic factors determine the actions of medicines.
In pharmacology, the term ceiling effect refers to the property of increasing doses of a given medication to have progressively smaller incremental effect (an example of diminishing returns). Mixed agonist-antagonist opioids , such as nalbuphine , serve as a classic example of the ceiling effect; increasing the dose of a narcotic frequently ...
Lipinski's rule of five, also known as Pfizer's rule of five or simply the rule of five (RO5), is a rule of thumb to evaluate druglikeness or determine if a chemical compound with a certain pharmacological or biological activity has chemical properties and physical properties that would likely make it an orally active drug in humans.